115-Cell Marker Accordion: interpretable single-cell

Paper Talk · Oct 1, 2025 · 16m

This research article introducing the Cell Marker Accordion, a new computational platform designed to improve the interpretation and automatic annotation of single-cell and spatial omics data in both healthy and diseased tissues. The authors highlight that existing tools suffer from inconsistent marker sets and poor interpretability, especially when identifying disease-critical cell populations. The Cell Marker Accordion addresses this by integrating multiple marker gene databases, standardizing nomenclature, and weighting markers based on both their specificity and evidence consistency…