983-Lipid-CLEM: Visualizing Nanoscale Lipid Distribution
The paper describes the development of Lipid-CLEM, a novel imaging workflow designed to visualize the nanoscale distribution of specific lipid molecules within cellular membranes. By combining minimally modified bifunctional lipid probes with correlative light and electron microscopy, researchers can now quantify lipid densities across suborganellar structures with high precision. This method overcomes traditional limitations in lipid imaging, such as rapid molecular movement and localization artifacts caused by bulky fluorescent tags. Using this technique, the study demonstrates that…
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