747-Benchmarking Xenium In Situ Data Analysis Workflows

Paper Talk · Apr 5, 2026 · 25m

This study provides an independent evaluation of the Xenium In Situ platform, a high-resolution spatial transcriptomics technology developed by 10x Genomics. By analyzing 25 datasets across various species and tissues, researchers benchmarked Xenium’s performance against several other commercial and open-source platforms. The findings demonstrate that Xenium offers superior sensitivity compared to Visium and achieves a detection efficiency on par with established imaging-based methods. Beyond performance metrics, the authors offer best-practice recommendations for computational workflows…