080-Glucose restriction promotes lung pre-metastatic
This research explores the paradoxical relationship between glucose restriction and cancer metastasis, specifically focusing on lung metastasis. The study reveals that while low-carbohydrate diets or impaired glucose metabolism can suppress primary tumor growth, they unexpectedly promote lung metastasis by altering the immune landscape. This occurs through exosomes containing TRAIL protein, which are released by glucose-deprived cancer cells. These exosomes then polarize lung macrophages, leading to the exhaustion of natural killer (NK) cells via the PVR-TIGIT pathway, thereby creating an…
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