268-PROGENy: Pathway Activity Inference from Gene Expression
The paper introduces PROGENy (Pathway RespOnsive GENes), a novel computational method developed to accurately infer signaling pathway activity in cancer from gene expression data. The authors highlight that traditional methods of mapping gene expression to pathway components are often inadequate because they fail to account for post-translational modifications and are often too context-specific. PROGENy overcomes these limitations by leveraging a large collection of public perturbation experiments to identify a common core of consistently deregulated genes that respond to pathway stimuli. The…
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