Episode 24 - Selecting and Individualizing PAH Therapy

Practice Point®: Pulmonology · Oct 15, 2026 · 20m

This module explores how risk status, clinical trajectory, right ventricular function, hemodynamics, and patient-specific factors inform the selection and escalation of PAH therapy. It reviews therapies targeting the endothelin, nitric oxide, prostacyclin, and activin signaling pathways and considers how combination therapy and route of administration can be individualized according to disease severity and treatment goals. Particular emphasis is placed on balancing therapeutic efficacy with treatment burden, lifestyle, adherence, support systems, and the patient's ability to manage therapy…