Acute Myeloid Leukemia — An Interview with Dr Ghayas Issa on the Role of Menin Inhibitors

Research To Practice | Oncology Videos · Oct 9, 2025 · 38m

Featuring an interview with Dr Ghayas Issa, including the following topics:

Mechanism of action and efficacy of menin inhibitors (0:00)

Presentation and management of differentiation syndrome (13:31)

Role of menin inhibitors in other cancers (18:19)

Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51)

Mechanisms of resistance to menin inhibition in AML (26:53)

Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31)

Mechanism of action of…