542-To Minimize Skin Fibrosis and Scarring
Recent research published in Cell demonstrates that facial fibroblasts possess a unique neural crest embryonic origin that allows them to heal wounds with significantly less scarring than fibroblasts from other body parts. This regenerative ability is governed by the SLIT2-ROBO2 signaling pathway, which maintains these cells in a less differentiated, pro-regenerative state. The study reveals that ROBO2 works through the protein EID1 to suppress EP300, a key regulator that otherwise promotes the formation of thick, fibrotic scar tissue. By applying a small-molecule EP300 inhibitor to dorsal…
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