Latest / In Search Of Excellence / Dr. Mike Roizen: Your Genes Are Under Your Control | E71

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Dr. Mike Roizen: Your Genes Are Under Your Control | E71 · In Search Of Excellence

• 0:00
  Michael Roizen: I'm actually 78.
• 0:00
  Michael Roizen: And my real age is around 57.4.
• 0:06
  Michael Roizen: But really, age is the actual age of your body, as opposed to your calendar age. And you really age can be many years older or younger than your calendar age, depending a lot on your habits. My life mission is to help other people do that as well as myself. You know, I'm a side effect of the test, if you will. So stress is a incredible ager. But again, by doing stress management, you get to change the effects of stress on you and your rate of aging. Very substantial.
• 0:48
  Randall Kaplan: Welcome to a Search of Excellence, which is about our quest for greatness and our desire to be the very best we can be to learn, educate and motivate ourselves to live up to our highest potential.
• 0:57
  Randall Kaplan: It's about planning for excellence, and how we achieve excellence through incredibly hard work, dedication and perseverance. It's about believing in ourselves and the ability to overcome the many obstacles we all face on our way there. Achieving Excellence is our goal and it's never easy to do. We all have different backgrounds, personalities and surroundings. And we all have different routes and hope I want to get there. My guest today is Dr. Mike Roizen. Dr. Mike is a world renowned physician and author whose work has helped 10s of millions of people improve their health and wellness through lifestyle changes, and whose purpose in life is to spread the message that we get to control our genes to a large degree. Dr. Mike formerly served as the chairman of the Department of Anesthesia and critical care, and Dean of the division of Biological Sciences at the University of Chicago.
• 1:41
  Randall Kaplan: And in 1997, he left there to co founded a company called real age, a consumer health media company that inspires people to adopt healthier lifestyles.
• 1:52
  Randall Kaplan: Shortly after selling the company, Dr. Roizen was named Chief wellness officer at the Cleveland Clinic, the first such position of the major healthcare institution in the United States. Dr. Mike has published more than 185 peer reviewed scientific papers, has written 18 books, including for number one New York Times bestsellers, and has received 13 and many foreign patents. Dr. Mike, it's a true pleasure to have you on my show. Welcome to In Search of Excellence.
• 2:20
  Michael Roizen: Randy it's always great to be on excellence. So thank you for inviting me.
• 2:26
  Randall Kaplan: So we met at the scale global summit a conference in Las Vegas about a month ago.
• 2:30
  Randall Kaplan: There are a lot of speakers there very prominent speakers from Mike Pompeo, and William bar jewel. Kimball mosque and I have to say, of all the presentations there, I enjoyed yours the most It was fascinating. I thought it was going to be boring. I've heard doctor speak at lots of different conferences, and they were okay. But this is it was spectacular. And I'm super excited to share this today.
• 2:56
  Randall Kaplan: With everybody listening and watching. Let's start.
• 3:02
  Michael Roizen: I gotta I gotta take Thank you. That's a high compliment. I was really the appetizer for Boris Johnson. So there was a medical speaker before each of the political ones and I was Boris Johnson's appetizer.
• 3:15
  Randall Kaplan: Boris was awesome, funny down to earth.
• 3:19
  Randall Kaplan: But you guys were neck and neck there. I mean, that's, that's a that's a great warm up. And he was awesome. But so are you, thank you, you're actually just 77 years old, but your real age is closer to 57. He explained the difference between real age and actual age. And we're Net Present Value figures into this calculation.
• 3:38
  Michael Roizen: Sure. And you got Net Present Value correct because this really started because we were trying to motivate patients to get 10 to 20 years younger in the perioperative period. That is, if you're 10 or 20 years younger, you have a 10 years younger, you have a three fold reduction in complications, or a three fold quicker return to function. And it's it, it seems to be logarithms. So logarithmic. So at 20 years younger, you're nine fold fewer complications. We got that from the database and cardiovascular outcomes in 1978. From The California study, and as you said, I'm actually 78 and my real age is around 57.4. But real age is the actual age of your body, as opposed to your calendar age. And your real age can be many years older or younger than your calendar age, depending a lot on your habits.
• 4:52
  Michael Roizen: We used to think this was all physiologic. For example, we used to think when you exercise you improve blood flow to the brain If you improve your cardiac function, you, you decrease the damage to your arteries. So you get the stay younger, but it's more than that you actually change which of your genes are functioning or not you, for example, for exercise, you turn on a small gene, a gene in the muscle that produces a small protein arisen goes to your brain, and increases brain derived neurotrophic growth factor. So one of the things that we've learned in the last 10 years is really that what you're doing when you make these changes is changed which of your genes is on which proteins you produce?
• 5:49
  Michael Roizen: Now, what is net value Net Present Value have to do with it? It is your choices, the net present value of your choices, just like the net present value of investments makes a difference in how long and well you live. And believe it or not, it's actually much more similar to investment than we thought, because compounding plays into it. So for example, if you lower your LDL cholesterol, your apolipoprotein B from 140 to 70, in the first 10 years, it may be a 6% reduction risk. But by 40 years, it's a 30% reduction in risk. There's a compounding of benefit, just like there is in investment. And that gives you the net present value of your house choice. Just like there's a net present value to investments.
• 6:40
  Randall Kaplan: When I'm calculating NPV. I'm going on an Excel spreadsheet. I know the inputs, I know the formula. How do you calculate that you're closer to a 57. Today? When and it's something that people would want to know I would think right? They want to know their score. Am I above? Or am I below my actual age?
• 6:58
  Michael Roizen: Well, you can go to actual age, the actual age test and our new app called longevity playbook at the longevity playbook.com. It is launched on June 15. So pretty recent. And on June 15, you'll be able to get your actual age test and do it and it has the inputs have actually about 60 inputs. The major inputs obviously, are your blood pressure, your LDL cholesterol, your stress management, your whether you are making unforced errors like smoking or vaping, your marital status, and how many orgasms you have, if you will, your fasting blood sugar, and a whole bunch of characteristics that allow us to gauge the net present value of your changes all put together.
• 7:59
  Michael Roizen: And yes, there's a lot of covariance used. Because obviously, some of the things affect the same areas such as blood pressure and LDL cholesterol both affect your cardiovascular risk your heart disease, strokes, memory loss risk, although blood pressure also for some reason affects cancer risk.
• 8:21
  Randall Kaplan: Well, the average person be able to go on your app and know all the stats if they're gonna have to call their doctor because I think most people don't know their cholesterol level and probably a lot of other inputs on that they
• 8:32
  Michael Roizen: don't. If they don't know those, they, they can either get them from their physician or they they've got many people have blood pressure monitors and out home. Or you can go to the drugstore for your blood pressure. But in fact, if you don't put those in, you still get your actual age might not counting those. And you can get those at a later time and add them in.
• 8:55
  Randall Kaplan: Let's move to your desire or your one of the themes is you can genetically engineer your DNA while you're alive. As opposed to when you're born. There's roughly 300,000 genes that are available. We've talked about you've talked about 22,500. And you've talked about concepts like junk DNA. So can you talk to us about the Human Genome Project, which I believe cost $4 billion when they were doing it and now you can get a sequence test at Walmart for$100.
• 9:26
  Michael Roizen: Right, except when it's on sale, it's on sale.
• 9:28
  Michael Roizen: Usually Mother's Day and Father's Day you can get it for$70. But in fact, that's right.
• 9:31
  Michael Roizen: The human genome project started in both in the private sector by Craig Venter and that by Collins at NIH, and costs around $3 billion to do each of them to do one genome. And when they started it, there was enough DNA in the nucleus that they expected to find 300,000 genes, but they only found 22,500 Each And so they said, what's the rest of the DNA and they agreed to call it junk DNA. But it was also funded by a large nine country project called the ENCODE to look at what it was.
• 10:11
  Michael Roizen: And in 2008 or nine, it was found that these are really switches that control your genes. And the great news is at least 80% of those switches you control, meaning all genes do is really produce proteins or watch other genes. And which of your genes are on or not, is largely under your control at least 80%.
• 10:38
  Michael Roizen: In the most recent two twin studies, one found 93 and one found 94% of those genes are under your control largely under your control. So that your habits really influence how your genes function. And those proteins those genes make influence are really how you function and how long and well you live. So you are a genetic engineer, and get to control it, whether you went to MIT or Caltech or not, you're much better genetic engineer for you than any of those are.
• 11:19
  Randall Kaplan: Right, we should also point out that I know you're joking about the schools.
• 11:22
  Randall Kaplan: But really, these techniques that we're going to talk about today are really applicable to anybody in whatever socio economic status no matter where you live in the world.
• 11:33
  Michael Roizen: That's exactly right, it is Your choices matter for you, no matter where you are.
• 11:40
  Randall Kaplan: He said 80%, we can influence we're going to get into the details of some of the amazing and simple things we can do. What's the 20% of our genotypes that we cannot control that will negatively influence our life expectancy?
• 11:53
  Michael Roizen: Well, we don't know all of that. But, for example, we're born some of us are born with dominant genetic genes that might cause if you will, sickle cell disease. And we know we can influence that through genetic engineering techniques that are really brought from the outside. But we don't know how to influence that, ourselves how to turn off that sickle cell, these genes producing protein produces sickle hemoglobin. But the good news is many of those 20% that we don't know, we get or seven or eight and six or 7%, in the most recent studies, that we're learning how to alter them with CRISPR, cast nine and the improvements on CRISPR cast nine. So there really are a huge things. Let me give you one more example. Stress Management, you say how important is that? Well, it turns off or on over 256 genes. And the majority of the genes that turns off, produce inflammatory proteins, proteins that increase inflammation. And the majority of genes it turns on that produce produce proteins that decrease inflammation. So stress is a incredible ager. But again, by doing stress management, you get to change the effects of stress on you and your rate of aging very substantially.
• 13:31
  Randall Kaplan: We're going to spend a little bit of time talking about stress management a little later, I want to ask you about the popularity and ease of getting these genetic tests. You mentioned Walmart, I think most people know 23andme is a leader in the space. It's$199. I've seen it on sale for$99. Online and a whole bunch of different websites on a lot of my social media, this pops up as well. Is it worth it to get this test? Does it be helpful? And can it add to give you recommendations for longevity?
• 14:04
  Randall Kaplan: Or is it pretty much designed to tell you if you have some lingering illness or cancer in your body?
• 14:14
  Michael Roizen: There really are designed to let you know what risk risks you have from a genetic standpoint. But you have to take action. So for example, if you have the a gene that predisposes to breast or prostate cancer, well, we know a lot about the things that turn those wrasse family of genes off and turn on the gstn one protein making genes that decrease breast and colon cancer propensity. Now, that means you have to take those actions, but those actions are I common, and so you can take them anyway, I believe that the 23andme and the other genetic tests in general, are let you give you a heightened awareness of yourself. But the key point isn't just that awareness, it is then taking action to rid yourself of that risk. And some of them aren't exactly accurate.
• 15:29
  Michael Roizen: As you probably know, I think I said, I drink eight cups of coffee a day. Well, if you go to my 23, and me, it says I'm a slow coffee metabolizer. Well, if I was a slow coffee metabolizer I wouldn't have a cups a day and be able to sleep well at night. So either I've induced around that by having progressively more and more cups of coffee, or that test isn't perfectly accurate yet.
• 15:57
  Randall Kaplan: I know a lot of parents today, including me, do cord blood when our kids are born. And I also know there's a lot of recommendations from doctors, pediatricians, who do genetic testing on newly born babies to determine whether there are issues, future material health issues going forward. In one case, we have a friend whose child is severely disabled and their disease wasn't caught until they were three or four years old. And now this young lady is unable to speak communicate is in a wheelchair for life and has a life expectancy of 21 years old, is genetic testing something that all parents should do when their baby's born. And is it something that parents should do on their kids later in life, regardless of their age?
• 16:46
  Michael Roizen: You know, I think that it will become more common and more useful. There are some genetic tests that that are mandated state by state. So for example, fetal kidney Nerea, and some of the other genetic diseases, their metabolic equivalents are measured. I think that over the next five to 10 years, maybe two to five years, we're going to find much more use for both pre NATO and NATO genetic testing or, or post birth genetic testing. And for genetic testing in the rest of us. We're still at the infancy of this, this field. And obviously, it's important in cancer treatments, different treatments, or different receptors, different genetic markers of breast cancer. But we're going to learn much, much more through what I would call the AI or the machine learning, plus the large databases that are now working with genetics to help us. That's one of the reasons that 23andme started, it was the really, as I understand their vision, to help people understand their risks and be able to cure the disease earlier. Now, there are some things that you should do definitely, if you will, when you're kids. So we normally test if I have a patient, and I take care of adults, and usually people 50 and older who want to get want to live to 110 in the same shape there. Now that's the goal with each of these patients they take care of but they someone has a high cholesterol, well, we measure it then in kids as early as six years old, and actually start treating it if it's there because of that compounding benefit effect that I talked to. So yeah, there, it's gonna be a lot. I think we're going to be able to have healthy longevity a lot more progressively as we go on.
• 18:59
  Randall Kaplan: It's interesting. I've never heard of a six year old taking anti cholesterol drug, for example, for future in life, is that a common thing? It's just something that I've never even thought about. I've never even heard someone doing that for their kids. And like I said, I've got five kids, we all talk about what you would do with cord blood and medical recognitions, Doctor referrals, all things like that.
• 19:23
  Michael Roizen: Well, we measure a whole bunch of things, their blood pressure, etc. So that it's the fact that he for example, were you Randy and hey, I have you should disclaim it. I have no idea what your what bookmarkers are, I don't take care of you, etc. But were you to have familial hypercholesterolemia? Yeah, we'd start testing your kids at age six. And I don't know whether that's just the Cleveland Clinic or just a few countries. But I think it's it is it there is a growing awareness of the value of Peru adventive care for the family, once you know some of the genetic markers, the adults in the family,
• 20:08
  Randall Kaplan: so you talk a lot about in your life mission is to alter your genetics to control them to improve quality of life and life expectancy. And you've identified 33 choices we could do.
• 20:19
  Michael Roizen: Yeah, by the way, let me correct just a little bit of that statement, my life mission is to help other people do that, as well as myself. You know, I'm a side effect of the test, if you will.
• 20:29
  Michael Roizen: But my life mission is to help every one of your listeners or every one of my patients do it.
• 20:38
  Randall Kaplan: Yes. Thank you for clarifying. You've identified 33 choices we could all make to improve our cognitive functioning, and it can decrease your rate of aging.
• 20:49
  Randall Kaplan: Can you talk about what some of these are, I think you've identified six big things of the 33. And we can talk about, some of them are super easy, some of them take no time, and some of them take a little bit of time.
• 21:55
  Michael Roizen: Yeah, there actually are 38 now that have been shown at least two studies in humans to change your rate of brain aging. So the big six are the ones that affect everything, normal blood pressure you wanted under 115, under 75. And that bottom number you don't want below 50 You want an LDL cholesterol or HeMan or apolipoprotein B below 70 You want your fasting blood sugar or hemoglobin a one C in what is the normal range usually, between 80 and 99. For fasting blood sugar under 544 hemoglobin a one C, you want your waist as measured at the belly button would you sucking in to be half your height, you want not to have coat Nene or vaping and products in your urine. For me the primary smoking or vaping or secondary or tertiary, you want your you want to do stress management as a routine. And to practice that with a posse and purpose. So having six friends you call routinely and are vulnerable to and a purpose in life as you have with excellence. And I have with helping people live younger longer. Those are the six big then there are two things that are the next and stress management is so important. We have that as a another one, if you will, seven, eight might be and I'm doing these kind of in order of importance. Eight would be doing the four components of physical activity that have been shown to make a difference Annie that's 10,000 separate stepping globalen Today, you don't like walking play badminton, play with your kids garden, whatever you do have step equivalents.
• 24:03
  Michael Roizen: And in the longevity playbook app we have those step equivalents, but you can look them up on the internet as well.
• 24:10
  Michael Roizen: The second thing is resistance training. You want to do that before cardio to build up your muscles so you don't get injured and the keys are the core. So the core exercises are push ups if you will lunges, wall squats bent over back row and missing one lunges I said lunges, squats bent over backwards arrow push ups and oh getting out of the chair without using your hands with with weights in your hands when you're young like you are and then the next one is speed of processing game again, we have them embedded because that important into the longevity playbook app but it is the brain HQ games, double decision and freeze frame have been shown to decrease dementia. Now those are all take some time but the speed of processing is only 18 hours over 10 years decreased dementia in a randomized controlled study starting at 73 or 70 for 10 years by 40 plus percent. So really huge decreases. Then there's some simple things more coffee is better. A tables that half a tablespoon of extra virgin olive oil, lycopene tomato sauce or watermelon. So they're really simple things.
• 25:46
  Michael Roizen: omega three fats you don't have to like fish oil, you can Do it with other with algo based oils.
• 25:57
  Michael Roizen: So there's some simple things like that. Another one is for smells a day, a decrease in that's really important for COVID because it decreases the in animal models, it decreases the plaque build up the amyloid buildup along the olfactory nerve and into the basal ganglia decreases those. And in humans, the we've got two studies now and four smells a day being decreasing your risk of dementia. So there are a lot of things that are relatively easy, that make a big difference to how long and well you live.
• 26:40
  Randall Kaplan: Let's go through a couple of days because you said, a few things that I want to come back to I think are very important for our daily behavior. You're talking in terms of cognitive functioning, and playing these games, that being said, 18 hours over 10 years, can you just get more into that calculation. And I know, most people say video games are bad for you. But in this instance, video games are good for you.
• 27:04
  Michael Roizen: Well, they're very good for you in preventing and in what they do, actually, we're learning. In a very preliminary study, what they do is turn on the gene that repairs your brain neurons. So one of the things that happens when you for example, when you exercise a muscle, you tear it a little bit, that tear causes the muscle to rebuild itself the next day, so that it's as if it says you can tear me today, but you won't be able to tear me in two days.
• 27:41
  Michael Roizen: Apparently, that happens with the brain too. When you use it and do it speed of processing, you cause a little injury. But that injury calls for a gene that produces the NP as for complex, which is a repair gene, it turns on repair protein at NPS war repair, that helps your gene repair it. So now what happens in this randomized study was I didn't lose 2800 people, for groups, memory games, if it will, executive control, games control, and then speed of processing games, the speed of processing games 505 in the first five weeks, two hours a week, in month, 11, two hours, twice a week, in month, 35, two hours for two weeks, total of 18 hours over 10 years, decrease the risk of dementia independent by over 40% and increased acetylcholine production in those key areas. So pretty simple to do that. And those were brain HQ games, they keep testing them and keep finding similar results. Now in three randomized studies in humans, so I'm a big fan of those in anyone can do them, they're pretty darn easy to do. And you should start while you're still computer. And obviously you're pretty gosh darn computer literate if you can use Riverside to record this and podcasts and anyone listening has enough skills to do it. So just literally 10 hours in the first month, four hours a month, 11, four hours in 135. And if you're similar to the people in the study, and I think most of us are those, they've now done three studies in different ethnic and age groups. But they started with 7383. It huge benefit. What I've noticed when I do this, when I did this and still do it is I recognize things in the periphery, I recommend when I'm driving a car, I'm much better able to spot things that are dangerous to me, and react successfully to them. So I think it is a benefit. And hopefully, that's pretty easy to do. So if you're doing video games, you want to challenge yourself with a timed video game that pushes you and so I guess, war, the worlds and all of the other video games, when you're playing against someone have a time component. So maybe the kids are getting smarter this way, or at least less likely that not be able to take care of themselves when they're 100
• 30:48
  Randall Kaplan: What are your favorite video games?
• 30:51
  Michael Roizen: Well, I got to Diet is a I spend a lot of time with brain HQ games and they have about 20 Different games on there. But, but I, it is freeze frame and double decision that they do the most. So i i Love Actually, I love doing freeze frame because I can beat almost anyone on it. I've practiced it enough.
• 31:14
  Randall Kaplan: So this is an easy, no, I
• 31:16
  Michael Roizen: gotta tell you my favorite. My other favorite game, which is not a it's kind of is I do jump rope. So jump rope increases your bone strength, it's the only thing we know that doesn't just maintain it, but increases it. It's as though you are injuring the bone a little bit and you turn on your osteo blast years, your ability to make more bone in your spinal cord, your spinal columns and your hips. And so I love doing that because it's a very aerobic workout in a short period of time. And you can carry a jump rope with you whenever you go on the road.
• 31:56
  Randall Kaplan: So you're saying you're approaching 80 years old.
• 32:00
  Randall Kaplan: And you're you look like you're in good shape when I when I when we spent some time together at the conference, your your trim and your lean. But you're telling me that you jump rope every day even take a jump rope to your way to travel and your
• 32:16
  Michael Roizen: Yes. That's That's true. Crazy. No, I can't tell you I can't I can tell you you can you can actually when I was on one of the times when I was on the Dr. Oz Show, I challenged him to jump rope. And I was beating him so bad. They went to commercial.
• 32:35
  Randall Kaplan: That's awesome.
• 32:35
  Randall Kaplan: I love that. So the cognitive games very easy to do. Right?
• 32:40
  Randall Kaplan: Not a huge time commitment. But when you talk about 10,000 steps a day, I think most people are going to listen to this and say there's no way. And it's sort of like we know we're supposed to work out every day. We know we know we're supposed to get some kind of cardiovascular activity to stimulate the heart, get the heart beating. But what are you going to say to people like me who starts their day at six 630 I've got kids, I come on five kids, I come home for dinner, spend time with my wife and the kids. And then when they go to bed, I'm back working in my office, my home office, which is where I'm recording now. And I'm working pretty much seven days a week I'm running for companies right now I'm writing a book, I've got this podcast, how am I going to get 10,000 steps a day am I going to take a two hour walk around the neighborhood while I'm on a conference call?
• 33:30
  Michael Roizen: How In fact, let me go. And that's actually one of the ways to do it. So over the last 20 years, I've had a treadmill desk. And all it is is a treadmill with a trekdesk tr e k, I don't have any relationship to the company. But they're wonderful desks because you can use it on a regular treadmill.
• 33:52
  Michael Roizen: And I do an awful lot of my reading. And my conference calls on that. When I get called by a friend or when I call friend or even when I'm playing calling my kids. I do walking when I'm doing that. So yeah. And so if I had my phone, I put it away when you said put it away for the for this but if I showed you my phone, I think it's on the other side of the room. But if I wouldn't got it, you'd see I do 10,000 I actually do a few more steps in that every day. But you get step equivalence. So say you're roughhousing with your kids or gardening that roughhousing with your kids may be 120 steps a minute. And gardening is about 83 steps a minute playing ping pong 100 steps a minute, swimming 120 etc. If you play squasher, racquetball or badminton, it gets up to 180 steps a minute.
• 34:52
  Michael Roizen: So you get step equivalence for everything you do. Even washing dishes and vacuuming. So the whole point is for you to get physical activity because that 10,000 Step equivalence, as I showed you the data, it came from a Japanese pedometer manufacturer is really trying to sell pedometers, but maybe the data because 10,000 is the number that decreases type two diabetes that reverses pre diabetes that decreases colon cancer that decreases breast cancer, that decreases heart disease that is the most effective at decreasing dementia. So yes, 4000 is better than two and six is better than foreign aid is better than six, and 10 is better than eight, but you don't get much more health benefits more than 10,000 a day.
• 35:44
  Michael Roizen: So when you do cardio, you probably get 150 to 200 steps a minute doing cardio or resistance training. So every now It counts.
• 35:52
  Randall Kaplan: You forgot pickleball the fastest growing sport in America do you play and what kind of calories we're talking about there? I imagine No,
• 36:00
  Michael Roizen: I, I am going to play. I should. I can't say that. But so I kept in the US team and the Pan American Games in squash. And squash is a racquet sport that is kind of a forerunner to pickup pickleball, if you will, and so I, I will pick it up someday, I haven't done it yet. I did give a gift of a couple of pickleball rackets and a couple of pickleball balls. And so I look forward to doing that. But you probably get in and I don't know if there's singles pickleball.
• 36:42
  Michael Roizen: But if there's singles pickleball, you're probably getting 120 to 140 steps a minute. In doubles, you probably get about 80 Steps equal once a minute,
• 36:52
  Randall Kaplan: you said something about caffeine and coffee that goes against conventional wisdom and everything my doctor has told me and I mentioned this to a couple of friends. I saw this presentation, and there's all these concrete things you can do. And they're super simple.
• 37:07
  Randall Kaplan: And I got a lot of pushback on this one, and said no, that's not true. Drinking four cups of coffee is one of the things on your list that increases longevity. Yeah,
• 37:17
  Michael Roizen: the interesting data is if you're a fast metabolizer, how do you tell if you're a fast metabolizer you have a eight ounce cup of regular coffee, and you don't get headache, gastric upset anxiety, or abnormal heartbeats in that hour. So assuming you don't get that, then the more coffee you drink. The lower your risk of Parkinson's disease of Alzheimer's disease of type two diabetes, and live eight other cancers, including breast cancer. And what's found for breast is usually found from prostate, but that hasn't been shown yet. And eight other cancers. But the real benefit I look at is it's been it decreases your risk of Parkinson's disease and dementia. And it appears to asymptote after six. So maybe you get more and more benefit up to six decaf gives you about half the benefit. And so, it may be that in fact, we get more benefit on prevention of liver disease and diabetes by going higher than six. But in any case, four to six cups a day has been shown to be probably the best thing we know for preventing liver disease.
• 38:42
  Randall Kaplan: The research shows that men burn 101 calories during a 20 minute sex session, or 4.2 calories per minute while women burn around 60 calories during sex or 3.1 calories per minute. How often should we be having sex and does having sex frequently an orgasm infrequently increase our longevity. We don't
• 39:03
  Michael Roizen: know cause from effect here. But the association and there are four studies on this prior to couple in the recent past. So there are now six studies on it. And the data is better tabulated in men and women because women can have multiple orgasms at one session, whereas men usually have one at a time. And men. The average 58 year old man has 58 orgasms a year, one per week. The average if you increase that to 351 per day, you are the equivalent of 16 years younger. So yearly with that alone on now we covary that a great deal on the program, because we don't know whether it's an association or cause for women it is the similar thing, but it is how satisfied they are with their sex life. The the data are pretty good that you can decrease erectile dysfunction that has continued to have more orgasms with a number of foods such as anything that will improve your arterial function, avoiding red meat avoiding processed red meat avoiding simple sugars, having lycopene that's the active component of cooked tomatoes and watermelon and a number of other things. But so there's a stir On correlation between choices and erectile function and orgasms, the strongest correlation at 58.
• 40:57
  Michael Roizen: If you're having orgasms at 58, will you at 85. In the they looked at that in the US social study, and they found that the strongest correlation, one having a partner who was still alive, if you had 158, the same partner at 85. And the second thing was a was your C reactive protein, your HS your highly specific C reactive protein level? That is the lower the inflammation level at 58. The more likely you were to still have erectile function in orgasms and 85.
• 41:38
  Randall Kaplan: I think there's a lot of people who just listen to what you said Dr. Mike, pretty psyched right now and say, hey, if I can have an orgasm have sex every day, I'm gonna live nine years longer. I think I think that's a stat that most people didn't know.
• 41:50
  Michael Roizen: Yeah, the data is that and we don't have we don't have enough data on to a day. But in fact, the few the one study that looked at and went that far showed that it was about twice as beneficial. So it may be a linear relationship.
• 42:10
  Michael Roizen: But that may be related to rate of aging. Maybe an association.
• 42:16
  Michael Roizen: So Randy, that's a goal for you.
• 42:16
  Michael Roizen: Okay, I think it was fine. It was worth five with five kids, you've probably already been doing something.
• 42:27
  Randall Kaplan: I'm not sure what I should and shouldn't say on the on the show. But I think men we can say that men can have two orgasms a day for certain 50 days here. I think some things are not humanly possible. Maybe they are for some people, but I don't know anyone.
• 42:47
  Michael Roizen: That's an average. You can have five a day in London the next day, Randy?
• 42:51
  Randall Kaplan: Okay. All right.
• 42:51
  Randall Kaplan: I think I'm gonna start charting it out with my workout schedule that I look at every day, I think I would have to add a new category to that. How important?
• 43:02
  Randall Kaplan: How important is it to have a supporting loving partner to increase our longevity to people who live alone and do have lower life expectancy than people who are together through some period of their life.
• 43:20
  Michael Roizen: Yeah, there are two different if you will, net present value calculations on this. One relates to stress. So you have three stressful life events, you're 32 years older.
• 43:34
  Michael Roizen: If you have six people you're vulnerable to including a spouse, you're only two years older. So huge benefit from stress reduction in having a posse, especially a supportive, if you will partner. The second thing is marriage itself, independent of that. So a happily married man is three years younger than a single man, irrespective of sex, if you will, irrespective of frequency of orgasm, and even a unhappily married man is about one years younger than a single man. Women only get a benefit if they're happily married in the the studies. There are a couple of the studies that have been done very well. The White House studies in Great Britain and the Alameda County studies by Berkman in the US where they looked at this very carefully.
• 44:36
  Randall Kaplan: Thanks for listening to part one of my amazing conversation with Dr.
• 44:38
  Randall Kaplan: Mike Roizen, whose work has helped 10s of millions of people improve their health and wellness through simple life changes that we can all make. Be sure to tune in next week for part two of my amazing interview with Dr. Mike Roizen.