851-Human Endoderm-Derived Organoid Cell Atlas
The paper details the creation of the Human Endoderm-derived Organoid Cell Atlas (HEOCA), a massive integrated dataset comprising nearly one million single-cell transcriptomes. Researchers synthesized data from 55 publications and nine different tissue types to harmonize cell annotations and establish a benchmark for organoid fidelity. By comparing lab-grown tissues to primary fetal and adult references, the study reveals how different stem cell sources influence the maturity and accuracy of models like the lung and intestine. The authors introduced sc2heoca, a toolkit designed to help…
The skinny
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