Latest / Ageless and Timeless Podcast® / Graham Simpson

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Graham Simpson · Ageless and Timeless Podcast®

0:10
Good morning everyone. This is Michelle Hughes from Ageless and Timeless. Today we
0:15
have a really wonderful guest. I want to tell you a little bit about
0:19
him. We've known each other for about I think twenty years, Graham,
0:24
you know, I think it's been that long. Yeah, doctor Graham Simpson,
0:28
who was a doctor that everyone should know about because he's doing a lot
0:33
of very important work, particularly with diabetes and although he's really an anti aging
0:39
doctor. But so Graham and I met many years ago and we've done some
0:45
interactions, some actually business transactions together, and we were both involved with doctor
0:53
Stephen Sinatra and doctor Barry Sears. We were going to start something that was
0:59
very sighting Graham I thought anyway, was called the Zone cafe, and it
1:03
was taking after it was after doctor Sears's revolutionary breakthroughs in the Zone if people
1:12
might remember that. And anyway, so we were the idea that Graham came
1:17
up with. I think it was your concept, Graham, to start little
1:22
Zone cafes all over the country and using the Zone diet and well, anyway,
1:27
the Zone you had one in Reno, right or Yeah, that was
1:33
a prototype and yeah, it was doing actually reasonably well and it was the
1:38
whole concept was to you know, people love fast food and then it's not
1:42
going to stop it. We wanted to sort of make delicious fast food that
1:47
you know, would help people with the nutrition, et cetera. Right,
1:51
right, Yeah, And so at that time I was doing my real estate
1:57
projects in Hawaii and I was having a big birthday. I can't remember which
2:01
number, but it was a big one. And we had the idea to
2:06
bring the chef from the Zone Cafe and we had a party for about I
2:10
don't know, five hundred people out on a huge property that we owned,
2:15
seven thousand acres, and we took part of it and created the like a
2:23
Zone Evening and it was hugely successful, particularly in Hawaii. I think that's
2:28
an amazing accomplishment because the people, many people there haven't quite arrived yet in
2:35
terms of their nutritional enlightenment. So anyway, but they loved the food and
2:39
we had a wonderful evening. And I was too bad, Gray and you
2:43
couldn't come. We live up this entire field so much so that the planes
2:47
coming in from Allahu had to divert and we got a little bit of flak
2:53
on that later, but anyway, they were all curious to see what all
2:57
these lights were out in the middle of nowhere. So anyway, but that
3:02
was our one, I think, one of our first interactions with many others.
3:07
So anyway, let me just give you a little background. So,
3:09
doctor Simpson, your you grew up in South Africa, right, yes,
3:15
correct? Yeah, in born in Cape Town and went to medical school in
3:22
Jehannesburg, right, And how did you happen to come to the United States.
3:28
Well, I went via England. My great great grandfather was Sir James
3:34
Young Simpson, who invented chloroform. Actually Queen Victoria's third child was done with
3:38
chloroform. But I had a context because of that at Hammersmith Hospital and I
3:45
was going to do obstetrics and gynecology. But I realized after a few months
3:51
that I was I wasn't crazy about the weather and things. So I decided
3:55
to move to the States and that's where I went to And how come did
4:00
you get to Las Vegas and then we'll also California. Yeah, I mean
4:05
I first, you know, started here in Vegas, and you know,
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obviously I did internal medicine and emergency medicine and things, and that was sort
4:16
of the first stop. And obviously, you know, Vegas was kind of
4:23
near and dear to me that at one time we used to run the early
4:27
emergency rooms in Vegas. This was back in the late seventies, so you
4:32
know, Sunrise and Southern ad A Memorial which became UMC University Medical Center were
4:38
the EO. So I suppose the first part of my life for twenty ideas
4:43
was in emergency medicine looking for all the acute stuff. And then obviously I
4:48
became more and more aware it's a lot easier to prevent, you know,
4:54
rather than try and cure, you know people. So you know, I
4:58
transisioned about twenty years ago into you know, really a more integrated, preventive,
5:04
proactive approach to medicine. So what what who inspired you? Where?
5:11
Where did you get your mentoring and your early development in terms of choosing the
5:17
alternative and holistic path versus a allopathic Yeah, I mean, you know,
5:25
when I was, even in my emergency days, I was very curious.
5:30
You know. I don't know if you remember Young Smuts. He was one
5:34
of the earlier presidents of South Africa, and you wrote a very interesting book
5:39
called Holism and Evolution in fact, the term holism, if you look it
5:44
up in the Encyclopedia Britannica, actually refers to his concept of emergent life forms
5:49
and you know, the whole being greater than the sum of its parts.
5:54
And I suppose, you know, reading some people like that. And there
5:57
were a lot of early you know people Paul Renee Dubois and others who you
6:01
know, were very instrumental. And we actually, I think back in the
6:08
late seventies or mid seventies, we actually you know, started a holistic health
6:14
sort of conferences in San Diego and a friend of mine, John Travis,
6:18
who really had a lot to do with putting the word wellness on the map.
6:24
You know, before that, the term wellness was used by a psychiatrist
6:28
called Herbert Dunn, and John Travis sort of took some of the concepts and
6:32
he had a center in Mill Valley. You know, this was back in
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the seventies, so you know, we were just starting to explore, you
6:41
know, what is wellness and what is wellness medicine. Mean, this was
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long before any wellness program started at corporate wellness and all that type of thing.
6:49
But Larry Chapman was one of the early pioneers, or this was more
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than thirty years ago, you know, introducing and I think he's done thousands
7:00
of presentations and sort of encouraged the whole wellness movement in the corporate world.
7:05
So you know, there were countless people. I think one of also one
7:11
of my favorite people was Larry Docy because he was very much about the mind,
7:17
body and the non local mind sort of aspects of medicine. So Larry
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I met in Dallas over thirty years ago, and I think my latest book,
7:29
actually, the one on Living Beyond a hundred, I actually dedicated to
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Larry. He was a real giant in the field. And there were many
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others, I mean at that time when I met him in Dallas, you
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know, I met a number of good nutritionists and you know, other people
7:49
in the exercise world. And you know, it's gradually over the years,
7:54
and particularly the last you know, twenty something years, we've been very much
7:59
interested in looking at some of the root causes of disease. And you know,
8:03
there's so much exciting you know material now happening with um you know,
8:09
AI and machine learning and epigenetics and all these kinds of things. So it's
8:13
been a gradual evolution, I think, and you know, really for the
8:16
last twenty years or so, I've just practiced proactive medicine and been out of
8:22
the traditional you know, out of the traditional medicine. Well, when just
8:26
curious because I was going to mention your new book, Living Beyond a Hundred,
8:31
and I want to encourage our viewers to look. I believe it's on
8:37
Amazon, right, yeah, yeah, yeah, there's a number. They're
8:41
probably about ten books, but the last one was Living Beyond a hundred and
8:46
sort of the concepts of living below five and then living beyond a hundred.
8:52
Living beyond five is really the first step I think in anti aging, because
8:58
what's affecting us now, Michelle, I mean, it's a it's a pandemic
9:03
of unprecedented kind of proportions. Is that eighty eight percent of Americans are now
9:11
insulin resistant and basically metabolic stress, which is insulin resistance, is responsible for
9:20
eighty percent of the deaths that we see in humans worldwide. And also,
9:24
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fascinating company, their products and the technology. So let's define some of those
10:31
terms because I think a lot of people get confused when we talk about metabolic
10:37
syndrome and insulin resistance and so so let's just take a deep dive for us,
10:43
start at the beginning and give us the overview. I just want to
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say as a preface to this that your book goes into a lot of detail
10:54
for the lay person. So I encourage everyone who is dealing with this type
11:00
of situation. If there's eighty eight percent of you out there, then that's
11:05
that's a huge population. So in your book, you do define and you
11:09
break down each of the blood tests that you can take that will measure your
11:16
pre diabetes, diabetes two, insulin resistance, glucose metabolism and so for so
11:24
anyway, give us some definitions so we can be a little more educated.
11:28
Sure, So obviously, just let me preface. Look, type one and
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type two diabetes or different Type one diabetes is where obviously the pancreas that makes
11:39
insulin is you know, destroyed often you know, in young people in the
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you know, in their teens and things. So that's a different type of
11:50
disease. And what I would like to refer to is mosty. You know,
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ninety five percent of people have type two diabetes, and most of these
12:01
people are fat. I mean, insulin resistance drives obesity, and it drives
12:07
diabetes, and it actually drives all chronic disease that we see. And this
12:13
is because the insulin. Type two diabetics have lots of insulin floating around,
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but it's so called insulin resistance. It's not working in the body. So
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you know a lot of people still give type two diabetics insulin, and to
12:31
be honest, insulin to overweight you know, diabesity diabetes. Diabeesity is really
12:39
the combination of diabetes and obesity because they often coexist. But giving you know,
12:45
insulin to a type two diabetic will actually increase their morbidity and mortality twenty
12:50
two percent. So you know what the treatment of you know, diabesity and
12:56
all these chronic diseases is to regain insulin sensitivity and metabolic flexibility. The prime
13:05
drivers of this pandemic globally that we sing, I mean half the world is
13:11
now fat, diabetic, and sick. So the drivers of this is quite
13:16
simple. It's sugar, grains, and adulterated plant oils, but particularly sugar
13:24
and grains. The average American is now eating one hundred and fifty pounds of
13:28
sugar ear and two hundred pounds of grain and five thousand teaspoons of adulterated oils.
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For instance, in England in the seventeen hundred, the average englishman or
13:41
woman only eight five pounds of sugar. And it has increased tremendously, And
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you don't have to look for if you look back, what happened. You
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know, we were hunter gatherers for six hundred thousand generations and then about ten
14:00
hours and years ago you know, we became agriculturist. That was the first
14:03
time that grains and these things were planted, and we were sort of maybe
14:11
six hundred generations of agriculturists of farmers. And then you know, obviously we
14:18
had the you know, the modern diet and obviously the ultramodern diet in the
14:22
last generation or so, which is I believe is the tipping point of what's
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happened. If I don't know if you know this, Michelle, but in
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twenty nineteen figures America for the first time, our lifespan dropped by two years
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and three months. For me, that was the tipping point where ultra processed
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food. And this, by the way, was before COVID. It had
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nothing to do with COVID. You know, we actually dropped this and this
14:50
I think is because of this pervasive you know, more than fifty percent of
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the calories consumed by modern Americans is ultra processed food, which is extremely toxic.
15:07
I mean, we now know that sugar, particularly fructose. You know,
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many of us, I think in medical school and things, we thought,
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well, oh, fructose is just you know, natural sugar. You
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know, it doesn't do any harm. Wrong. I mean, fructose is
15:22
more toxic than than glucose, and so you know, fructose goes straight to
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the livers to start giving you insulin resistance. I would I would say,
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now one in two people in America have fatty non alcoholic fatty liver disease.
15:37
One in two people. It's just incredible, And eighty eight percent of the
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population is basically insulin resistance, meaning that that on that downward spiral to you
15:50
know, create lots of chronic disease. Most Americans by the time they get
15:54
into their late fifties and early sixties have one or more or two or more
15:58
chronic diseases. All these diseases hypertension, strokes, heart attacks, cancer,
16:06
Alzheimer's ED. I mean, seventy five percent of men with erectile dysfunction have
16:12
basically diabetes. It is the major cause of these things. And often once
16:18
that ED happens, that's usually like the canary in the coal mine, which
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means that within you know, probably four or five years, that person is
16:26
going to have a heart attack. So it's incredibly important for doctors to start
16:33
connecting. You know, the reactive disease medicine system is so screwed up.
16:40
You know, all you do with your diabetes. Now you go to the
16:41
doctor and each year or every six months, he starts increasing usually more medication,
16:47
more medication. The truth is, diabesity can be reversed in four to
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six weeks. I have another book called the four Week Diabesity Cure. But
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I'll tell you have funny story that maybe your listeners would find interesting. I
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mean, I was in I spent about ten years in the Middle East,
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and obviously you had a lot of contact in India and in Pakistan and other
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places. But in India we started using these little sugar glucose monitors. In
17:15
those days, it wasn't like the Libre Freestyle where you could have your own
17:19
little phone measure these sugars, and those days it was the libre freestyle pro.
17:25
So what we would do is we'd put on a little sugar sensor and
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if I saw you and you were the diabetic patient, I'd say, look,
17:33
Michelle, you know, don't do anything, keep taking your medicine,
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just eat your diet, and you know, give me some idea, record
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your food a little bit and come back and see me in four days.
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And you'd come back, and you know, I'd look at your figures,
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and you know, your sugar might be two hundred and three sixty all over
17:48
the place, but very high. And then I'd stay to the person,
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Look for the next four days, I want you to eat off my green
17:56
sheets. Green sheets were essentially a key too type diet was high fat,
18:02
moderate protein, low cards. And I'd say, do me a favor if
18:06
you can try and eat dinner early and breakfast late by intermittent fasting. And
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I'd say, look, why didn't you come back in four days? I
18:15
t Michelle. When I saw these things coming back, I thought these these
18:18
little sugar monitors weren't working because they would come back in four days and their
18:23
sugars would be normal. I thought to myself, Oh my god, how
18:26
did this happen? And sure enough it shows you with just a little attention
18:33
to the body, the body has incredibly healing potential. In fact, in
18:38
well documented medical research, you can actually reverse one third of your fatty liver
18:45
in as little as seven to ten days. That's another shocking thing that I
18:49
read that you know, with very sophisticated tests looking at the amount of fat
18:55
in the liver. You know nowadays, I don't know if you know this,
18:59
but non outkay fatty de libty is the major reason people are having liver
19:02
transplants. And we are seeing you know, you know, bad fatty liver
19:07
disease in teenage kids and many of these you know, these young kids now
19:11
I've all got type two diabetes. So you know, it's it's an absolute
19:15
global fiasco. And there's so much money being wasted in terms of more and
19:22
more medication. They never look at the root causes of these disease, which
19:26
is very frustrating. You know, when I was in the EI in the
19:30
old days, I mean, you know, we'd have most of these people
19:32
coming over the cute heart attacks and strokes and all the type A fat diabetic,
19:36
et cetera. And I want to say also at this point, fat
19:40
does not cause heart disease. This was a myth by Anzel Keys in the
19:47
seventies. Basically a physiologist who never saw a patient in his life. And
19:52
guess what the average person going to his doctor and the cholesterol's a little rays,
19:56
what does he do? He gets put on statins. Statins have one
19:59
hundred and forty four side effects, not only that it can cause diabetes much
20:03
higher incidents. Everyone on a statin has cognitive impairment. So, I mean,
20:11
it's just it's just amazing, not only cognitive impairment, but muscle,
20:17
oh yeah, absolutely, and pain, all this type of They don't tell
20:22
them to take cocutan or you which which still help to offset the negative impact
20:30
of the of the staton And yeah. So, and I mean people don't
20:36
realize in fact, this is well proven. The higher your cholesterol is over
20:40
the age of fifty, the longer you live. You know, your brain,
20:44
your brain is sixty five percent plus cholesterol and things. All your membranes,
20:48
every one of your trillions and trillions of cells, is all you know,
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the membrane is all cholesterol. All your hormones come from cholesterol. You
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know. I see people that come to see me and they've got a cholesterol
21:00
of one hundred and they wonder why they conquer directions. They've got no testosterone
21:04
because this is where testosterone comes from. It all your hormones come from cholesterol.
21:11
So, you know, I'm just so upset with the current healthcare system.
21:15
It's just it's just to me, it's a it's an absolute debacle.
21:21
Well, you're absolutely correct, and it's very shocking that America. You're one
21:26
of the most. You know, the leader in the free world has one
21:29
of the worst healthcare systems. We're way down. What are we number like
21:33
forty or something in the healthcare actually number forty four, and we spend more
21:38
than twice sometimes more than three or four times other countries, you know,
21:44
expense on healthcare. I mean, I think in twenty one it was four
21:48
point three trillion dollars, so I mean it's crazy, you know. And
21:53
then you know, having your your bypass or something, you know, two
21:57
hundred and fifty thousand dollars, and it's interesting. Countries like India you can
22:02
get a bypass for five thousand dollars with a better result than maybe clinic seventeen
22:07
percent lower morbidity and mortality in India because you know, again India is a
22:15
country also with you know, half the country's vegetarian. When you eat your
22:18
vegetarian diet, you're much generally speaking, you're at a much higher risk of
22:23
getting you know, diabetes and things like that. So you know, it's
22:30
it's really an interesting thing. And anyway, what I wanted to say is,
22:33
look, ideally you want to get your hemoglobe and a ONEC below five,
22:38
your uric acid below five, and also you're fasting insulin below five.
22:44
For me, that's the toxic triad. And I want to really commend David
22:48
Pilmartin his book Drop Acid, which is a great little book on uric acid,
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and you can see how toxic uric acid is. Uric Acid only comes
22:57
from three primary things. By far, the most important is fructose, alcohol,
23:03
and obviously very high purine meat. Fish diets can do it, but
23:07
that's the rare cause. Most of it is coming from fructose, and fructose
23:14
is terribly dangerous because not only does it give you insulin resistance by going straight
23:18
to your liver, but it also poisons the mitochondria. The mitochondria are the
23:23
common link between probably all metabolic diseases and mental diseases. I was very pleased
23:30
to read a book by Christopher Palmer, a psychiatrists from Harvard just a few
23:37
months ago. It's a relatively new book and it's called Brain Energy. But
23:41
he points out, and I really believe this, He makes a very good
23:45
case for it, that all mental disease from minor things like depression and anxiety,
23:51
all the way to things like schizophrenia, major psychosis, and major depression.
23:56
It's all related to the energy balance inside the brain. And this wasn't
24:02
actually all that knew. There was also a guy called John Wilson who's just
24:06
a family practitioner, but he had also collected There were a couple of doctors
24:11
at McClean University many twenty thirty years ago, but there was this whole group
24:17
of fifteen diseases, mental diseases they couldn't really quite find the cause for.
24:22
But I think that you know John Wilson, I think the name of the
24:26
practitioner who I actually haven't met, but i'd like to. He basically figured
24:33
out that most of these people all had what he called carb syndrome, and
24:38
it was basically he's done probably fifteen thousand body fats. And remember this is
24:44
very important. Most doctors don't even have a body fat machine in their clinic.
24:48
But your body weight and your BMI don't mean Daddley squad. You have
24:53
to know your percent body fat. A woman should not be more than twenty
24:59
eight percent, a man not more than twenty percent. Once that starts happening,
25:03
you can guarantee their insulin resistance and they're on their way to a whole
25:07
host of chronic diseases and I'm just shocked that, you know, ninety nine
25:11
percent of the doctors in the country do not have a body fat. And
25:15
you can also get skinny fat. I learned this also in India. I'd
25:18
see these young, little thirty year old girls. They look like little skinny
25:21
waves, and you put them on the body fat machine and suddenly you'd find
25:25
they had thirty eight percent body fat. And so these are the so called
25:29
skinny fat they call them tofis thin on the outside but fat on the inside.
25:33
And these people all have metabolic syndrome as well, so it's very interesting.
25:37
I also want to say something about metabolic syndrome. Look animals, and
25:44
this wasn't my idea, but I think Davis said this, But the animals
25:51
they actually develop metabolic syndrome and insulin resistance. Why, for instance, eskimos
26:00
they eat, or bears, they're eating all the fruit and things in the
26:03
summer, and then they obviously go and hibernate and they have their little offspring,
26:07
and you know, for four or five months, the bear doesn't eat.
26:11
Basically he's living off he's fat. So they actually burn ketones I mean,
26:18
and it's also very surprising. I often wondered about that. You know,
26:21
how do bears pa, Well, they don't because ketones are very clean
26:26
fuel, and it's probably our major fuel. Glucose is like a secondary I
26:33
think we have evolved primarily and everything works better, particularly our mitochondria. So
26:40
the point is that animals turn on this fat switch which is in the mitochondria,
26:45
and they accumulate fat. But then in the winter time like eskimas,
26:52
yeah, I mean not like penguins sitting on their egg, you know,
26:56
in the Arctic. Therefore four you know, they can live. The penguins,
27:00
emperor penguins can live at least four months without any food. They all
27:03
develop metabolics under In fact, even a hummingbird eating fructose all days, he
27:08
develops a liver, you know, fatty liver, and then overnight the fatty
27:14
liver disappears. So these this is a normal process. But in humans we
27:18
don't turn the fat switch off. The hibernating bear or the you know,
27:23
the the hummingbird or the penguin, they turn their fat switch off. Humans
27:30
we do not turn our fat switch off. Most Americans now eating six meals
27:34
a day breakfast, lunch, supper, you know, mid morning snack,
27:38
mid after in his evening snack no Wonder, you know, no wonder,
27:44
fifty four percent of Americans or diabetic or pre diabetic. It's just absolutely nuts.
27:52
Graham on the fructos issue, because I think a lot of people,
27:57
you know, don't really know what is fruct So can you just give us
28:03
a little list of those no no foods? Yeah, absolutely, absolutely.
28:11
Look, it's not just fructose. I mean, you know, I just
28:14
want to say something about these artificial sweetness. These things are totally toxic.
28:18
I mean, they we knew this from the sixties and seventies where you know,
28:22
they gave mice, you know, coke and dike coke in two groups,
28:26
and the diet coke rats get fatter, and we see this in some
28:30
of the fattest clients we have around the world, or you know, drinking
28:33
six or eight ten diet cokes a day and things. So you know,
28:37
it's not just fructose. These are artificial sweetness. But they have their main
28:42
effect in the microbiome, which we can talk about a little later. But
28:45
the microbiome is incredibly important. Most humans don't know that they're fifty percent bugs
28:51
and fifty percent human, and you've got much more genetic material in your microbes,
28:56
in your gut. But anyway, getting back to the foods, look,
29:00
one serving a pass mutty rice is ten teaspoons of sugar. One glass
29:06
of freshly squeezed orange juice is seven teaspoons of sugar. A medium banana is
29:11
seven teaspoons of sugar. Now here's the important thing. A normal, healthy
29:15
amount of sugar for a woman is six teaspoons a day. You have your
29:21
glass of orange juice, you've already exceeded. And as soon as you go
29:23
above six and a man nine teaspoons and sugar, you start developing fatty liver
29:29
disease, just like the penguins and the bears. So, I mean,
29:32
this is just you know crazy. We've got so much you know, sugar
29:36
coming in all you know, one hundred and fifty pounds plus per person per
29:41
year, plus the two hundred pounds of grain that also all turns into sugar.
29:45
So it's no wonder you know, our lifespan, our you know health
29:51
spans are being so totally corrupted. So the LB five LB one hundred plan
29:59
that we do LB five has to be to reverse this insulin resistance. But
30:04
basically not, I mean, we are now using some of these peptides,
30:08
like you know, semigluetide, but basically a well formulated keto diet, some
30:15
intimate and fasting, some semigluetide, a little walking every day, and you
30:19
know, basically we use a couple of supplements that are very effective and I
30:26
mean you literally can cure your diabetes literally and we do it every day.
30:32
We've got thousands of patients who've done it. And basically, once you do
30:37
that, you can then look towards you know, all the longevity and emerging
30:42
longevity sort of techniques that you know, you're very interested in, I know,
30:48
with your podcasts and things. But it doesn't make sense to spend all
30:52
the money on these longevity techniques unless you've got your hemoglobe and a ONEC and
31:00
and uric acid you know down under control, a normal uric acid for a
31:03
woman's three point five and for a man four point five, and um,
31:07
you know, most of the people I see uric acid and fasting insulins and
31:11
a one sees all way way way way high, and the the other thing.
31:17
Then for the normal person who doesn't want to ever hear the word diet,
31:25
you know, the type two diabetes then should they start meeting fruit if
31:30
they're you know, they're totally healthy, but they don't want to incur a
31:34
future was type two of fruit toose being a root cause? Would would that
31:38
mean that all fruit has to get off the diet or are there any fruits?
31:45
So? Yeah, so look they're obviously you've got you've got some good
31:51
tables that show, you know, obviously some berries and yeah, blueberries,
31:57
strawberries, the red berries have you know, and the and the blackberries are
32:02
all fine, but you know that it has to be in moderation as well.
32:07
The you know, you can't be having a big bowler berries every morning
32:09
for breakfast. But the other thing is that you were mentioning the um you
32:20
know what to do? You know, should people eat fruit? Looks there's
32:22
also clearly a small genetic component. I mean, I would say fifteen to
32:28
twenty percent, and most of it is epigenetic. It is mostly your lifestyle
32:34
that contributes. But you know, if both your parents and your grandparents and
32:37
everyone had diabetes, that would indicate to me, Look, there's some genetic
32:40
propensity here and we can measure this now with methylation data quite easily. But
32:46
those people will should probably be very cautious with the amount of fruits that they
32:52
eat. And again, you know, these sugar monitors are great for showing,
32:55
you know, what happens to your blood sugar after you have you know,
33:00
a bowl of berries or a couple of oranges or something like that.
33:02
So there are ways of easily measuring this. But generally speaking, you know,
33:08
some fresh fruit, you know, added to the dietematicularly, some of
33:13
the low glycemic fruits you know, some people can have. But if eighty
33:17
eight percent of the population is insulin resistant, well that's your answer. You
33:22
know, how can you start eating lots of fruit? I mean you can't.
33:28
And so I know online there as there are NEMDAR charts that show the
33:32
glycemic induct So I guess one first step for a lot of people who are
33:37
proactive about their health and preventing factor diabetes would be to look copy that glycemic
33:44
inducts. Yeah, and remember that comes with the glycemic load. The glycemic
33:50
load is actually more important than the glycemic index. But yeah, so you
33:55
really need both, you know, to see. But yes, it's a
33:59
good you know, it's a good indication in those tables or you know,
34:02
freely you know, freely available. I mean when you look at them,
34:07
the grams of carbohydrates, which I think is the most important of the macro
34:10
nutrients to count. And remember, I mean just information is that. Look,
34:16
carbs is what drives your insulin way way high protein. If you eat
34:23
too much, you can get a bump in your insulin from the protein.
34:27
But the only macro nutrient doesn't bump your car I mean, your your insulin
34:34
is fat. Fat is really your friend. Healthy fat is really what we
34:38
need. And this is where I'm you know, incredibly mystified by Ansel Keys
34:45
because because of his his you know, results which were not corrected so called
34:52
twenty two and then became seven countries study. Um, this is where the
34:57
dietary guidelines of America problem because you know, he had this postulate that,
35:02
oh, you're you know, your plumbing problem, your cholesterol get builds up
35:06
in your arteries, you have a heart attack, which is absolutely nonsense.
35:08
But here's the here's the thing. We change, the government change and and
35:15
basically Keys was directly responsible for us decreasing our fat intake to about thirty thirty
35:23
five percent and increasing our carbhydrates to fifty five percent or more. You know
35:30
that the old you know that little triangle where you know, this was the
35:34
pyramid, you know, the food pyramid. You know, even their American
35:37
Heart Association was saying you have to eat sixty twelve servings of carbhydrates and you
35:44
know all this and you know, drink some fruit juice and all this stuffing.
35:46
I mean, we are basically poisoned, not only America but the rest
35:51
of the world. So this was such bad advice. And you can see
35:55
the amount of diabetics, heart disease and all these things check as you know,
36:01
as we changed the macronutrients about diet. And remember Criticon and doctor Dean
36:07
Orners. I bet I'm pretty sure doctor Orners, who's lived here in Sarsilito,
36:14
right next door to me and where I am in tiberon Um. I
36:19
actually he was. He rented my house in Hawaii one time, and I
36:22
remember having a conversation with him about his change of belief systems because he was
36:29
one of the originals that was the low fat you know, no more than
36:32
ten percent of fat in your diet daily was was the kind of mantra that
36:39
was guiding people back then. Yeah, and it was really I mean,
36:44
you know, prittic in these things. That was well meaning and obviously cutting
36:47
out a lot of the crep out of the diet, which they did.
36:51
You know, I helped them. But you know, the truth is men
36:53
who eat just a ten percent low fat diet like Criticon and these guys,
37:00
they actually four out of five men will have an atherogenic profile, you know,
37:07
with small LDL and you know you can measure this now you know,
37:13
peleiacuratey and then very interesting if you go up to you know, twenty percent
37:19
to twenty five percent of fat diet, the instead of four out of five,
37:24
you know, three out of five people, you know men have an
37:28
aterogenic and then people are eating forty five percent plus you know, only about
37:32
one out of five men have an atherogenic profile. So we know, look,
37:38
hunter gatherers, there's very little archaeological evidence, anthropomorphic evidence, you know,
37:45
any kind of evidence to show that humans ever ate just a pure plant
37:52
based diet. So there is some truth that as we get older, because
37:55
of nutrient sensors like mtall which you know, we don't want to eat too
38:02
much red meat. I think as we get into our you know, sixties
38:06
and seventies, you want to maybe eat a little more fish, a little
38:08
more plant based diet. But you know, I really believe that for most
38:13
of human history, you know, at least for the last I don't know,
38:15
hundreds of thousands, you know, several hundred thousand years. I mean
38:20
we always date you know some you know, meat and fish and berries and
38:24
fruit and things, and you know we were omnivores. I mean I believe
38:30
that. I mean, I know some people go to the extreme now they
38:32
do carnival diets. Yes, you know, there are a lot of good
38:36
things, but they also you know a number of deficiencies. And you know
38:38
there's the same thing with vegans. You know, those are the two extremes.
38:42
So I think somewhere in between is what makes sense. And the other
38:46
thing I think is so important. And I learned this from I think some
38:51
Noaks in South Africa. You know, one of his great books was called
38:55
you know Real you know, real nutrition, And you know, I think
39:00
if you eat real food, not packaged or boxed or tunder you know,
39:06
if you eat real food, you largely will you know, limit the amount
39:10
of sugars and things you put in you know, into your body. So
39:15
let's talk about the healthy fats. Because we don't want people to listen to
39:20
what you're saying today and think, oh, I can go eat canola oil
39:23
or safflour oil or some of these transpants that are very unhealthy. So give
39:29
us a shortlist of the healthy fats yeah to be including in our diet daily.
39:37
Sure, so you know, also the other whole thing about you known
39:42
e. C. Polyctera, fats, et cetera, et cetera. But
39:45
a couple of important points. Look, when you cook, you don't only
39:49
use olive oil. Olive oil is great cold on your salads and things like
39:53
that. But you want to cook with butter. I usually advise people to
39:58
get you know, the kerry gold grass fair Irish butter, which is good
40:01
to cook with. All what Indians use, which is gee, you know,
40:06
the geese. Some people don't like the taste of gee, but gee
40:07
has a very high smoke point. The reason you don't want to use plant
40:12
oils of any There are a couple you can you You can cook with coconut
40:16
oil or avocado oil, but all things like pam sprays and canola and safflow
40:22
oils and olive oil, you don't want to heat olive oil. You know,
40:25
with a little balsamic or lemon juice. Great on your salads. But
40:30
and you do that because the only time cholesterol maybe does any you know,
40:34
bad things to you is if you know, if you oxidize the the the
40:39
fats there with heat, you can get you know, more of these LDL
40:45
particles, the smaller ones that can get you know, under your endothelium and
40:47
things. But for the most part um you know, healthy fats I mean
40:52
from meat, from fish, you know, from yogurt, I like yogurt
40:57
also for the for the you know, for the for the microbiome. You
41:00
know, the microbiome loves fermented foods. And obviously you want to get yogurt
41:06
without all the berries and things because they tend to be very very high.
41:08
So you just have plain phage yogurt or Greek yogurt and you know, things
41:14
like that are healthy. And butter, believe it or not, is you
41:19
know, I know there was a Time magazine picture which was great. They
41:22
had a piece of bread with a butter on top. Well, you know,
41:24
if you believed the keys, you'd never eat a block of butter in
41:28
your life. And you know you'd eat the carbydrate, which is absolutely wrong.
41:31
You're better off eating the butter than you are the cards. And also
41:35
remember all the flour and eyes, most of it is now contaminated with glyphosphate
41:39
you know, roundup, so it's very toxic. Roundup is tremendously toxic to
41:45
the microbiome. You know, one in six people now supposedly have some type
41:49
of autoimmune disease. And all this autoimmune disease comes from a leaky gut,
41:54
which is very much related to you know, what we're eating. And obviously
41:59
people should be careful of taking you know, PPIs and non steroidal anti inflammatories
42:04
and antibiotics. I mean, all this is incredibly toxic to the to the
42:08
microbiome, which is very very very important, and you know, the mitochondria
42:15
also terribly. I mean, I believe in all the hallmarks of aging that
42:20
Carlos Lopez turned you know, published in twenty thirteen, he had nine hallmarks
42:28
of aging, and obviously the microbiome wasn't actually included there because it was still
42:34
new and you know, research was just coming out. But you know,
42:37
those those ten hallmarks of aging to me are all affected by metabolic stress,
42:45
which is insulin resistance, and psychological stress I mean that is the major reason
42:51
we age, we get premature disease, our health span is shortened, and
42:54
our life span is shortened. So and I'd also like to mention something.
43:00
I don't know how much time we have left, Michelle, we have a
43:02
few minutes to talk about epigenetics. Yes, let's see, we have fifteen
43:08
minutes, so we're good. Oh okay, good, So look epigenetics.
43:13
Let me explain genetics. You know, we finished I think the Human Biome
43:20
Project from nineteen ninety I think there was two thousand and three, and we
43:23
thought, whoh okay, now we've deciphered deciphered the all the DNA that we
43:30
should be really able to cure a lot of metabolic and chronic and you know,
43:34
all these diseases. But to be honest, we've really come up short.
43:37
There's very little evidence that we have to date that many of the things
43:43
we die from is directly related to the genetic You know, the genes are
43:49
the hardware what we now realize, like often tell patients, genes load the
43:55
gun, but your lifestyle pulls the trigger. Your lifestyle is basically the epigenetics
44:02
which were described by Waddington back in the forties but it's epigenetics means above the
44:07
gene and what we now know is that genes are turned on and off all
44:13
day long, all the cells and what turns them on all these epigenetic things.
44:20
And so for instance, just to give you a little short thing,
44:22
look in twenty thirteen, Steve Hoarbworth from UCLA had a pan tissue clock.
44:30
It was the first age clock, but it actually measured so much your biological
44:35
age, it measured your chronological age. And then Morgan Levine from Yale in
44:39
about twenty nineteen had a second generation clock, which was where she took you
44:45
know, nine different things and there was some correlation. They looked at,
44:51
you know, what methylation things were causing disease and what I want. But
44:54
the one I really want to talk about as a plug for a friend of
44:59
mine, basically Ryan Smith, a true diagnostic. I believe that Ryan has
45:06
the best age clock currently out there. I don't like David Sinclair's one.
45:10
You know, I tell your Health they don't have the data and research that
45:15
Ryan smiths. And they measure basically nine hundred and fifty thousand CpG units on
45:22
your DNA and they give you a nice seventy six eighty page report. And
45:28
what is the most important thing I find there is you can measure your pace
45:31
of aging. That means normally, if you think about chronological and biological age,
45:37
normally it's like one to one, right, you get one year older
45:39
or one year biologically your organs or one year younger. Well it's not true.
45:44
We now know. And you see this every day, Michelle. You'll
45:46
see people you know they're forty years old and they look like they're seventy,
45:51
and vice versa. You know, you'll see some people seventy and they look
45:53
like they're in their forties. So this is the phenotypic biological aging. What's
45:59
how And here's the most important thing. If you can because age is your
46:04
biggest risk factor for chronic disease and death. But if you can lower your
46:10
biological age by just seven years, you can lower your risk of all chronic
46:15
disease by more than fifty percent. So let me just tell you a little
46:21
bit about pace of aging. I think your listeners would find it interesting.
46:23
The pace of aging study was actually done because of people from dun Eden,
46:29
which is in the South Island of New Zealand. Back in nineteen seventy six.
46:34
They took about fifteen hundred people that were born and they've been following them
46:38
now for over fifty years. And what they did they looked at a lot
46:43
of the markers. You know, it might have been grip strength, or
46:47
your gum health or your brain health. And you know, they're doing mrs
46:52
and doing all these studies on these people, and they correlated and showed how
46:58
people by a doting some healthy lifestyle changes, you can actually slow down up
47:06
to six months in any one year. You can slow down your biological age.
47:10
If you're screwing up and you're drinking and eating too much and stress and
47:15
too much fructose and all these things, too much alcohol, you actually advance
47:19
your biological age. But for you. So, I don't think anti aging
47:24
will be able to be practiced without using something like true diagnostic test, because
47:31
you want to know if you going to your doctor for an anti aging program
47:36
or you're taking a bunch of these neutraceuticals or pharmaceuticals, you want to know
47:40
that these things are making a difference. It's slowing down your biological age,
47:45
which should really be the goal, you know, of any anti aging program.
47:51
So you know, I'm excited and I'm embarking now on a study where
47:57
we're looking at seeing just our live below five program, where we can you
48:02
know, put people on a program just for three months. You know.
48:07
I believe once we start, you know, dropping all these these some of
48:12
these blood biomarkers like hemoglobe and AEC and things, I believe very strongly that
48:19
we are going to see market changes in biological age in a very short space
48:22
of time which we've never been able to see before. So I really think
48:29
that people are going to hear a lot about epigenetics in the years ahead.
48:35
What do you think about measuring telomeres and the DNA? Do you feel that
48:39
that's also the hallmark? I mean, I mean, look, I love
48:44
the book by the lady which was the named Blackburn, Elizabeth Blackburn, and
48:51
also the gag from UCLA, you know, the tilomere effect. And what
48:55
was very interesting in that book, which also I think validates some of my
49:01
thinking, is that the metabolic stress and psychological stress. Definitely they showed shortens
49:09
your teleomes and obviously shorter tileomes you probably have a higher risk of dying.
49:14
However, the tilemere, which by the way, true diagnostic measures the telomeres,
49:20
but they are not as predictive and as accurate for truly measuring biological age.
49:27
It is somewhat correlated, but not as well as these epigenetic tests.
49:32
But you know, in the Tilemere effect, I think what was very interesting
49:38
is you could see that, you know, if you had a parent with
49:42
Alzheimer's and you were the primary caregiver, or if you had a you know,
49:45
some child that had some bad sort of medical issues and you were the
49:51
prime care there, these these people's telomere shortened because of the psychological stress that
49:58
you know, the these people felt. You know, you can you probably
50:01
I don't know if you've ever had someone with a parent with Alzheimiers and things.
50:05
It's a tremendously you know, you can't leave some of these people alone.
50:08
You have to be with them pretty much twenty four seventh. So it
50:12
is a tremendous stress on the body. And you know, I think the
50:15
whole mind body, you know, a thing which we've only really been that
50:21
aware of in the last fifty sixty years, is tremendously important. I mean,
50:24
every thought you have in your head registers a physical effect in your body.
50:30
So I don't think you know, the DNA testing per se. Yes,
50:35
it will give you some ideas, but I think the epigenetic test is
50:39
where the gold is. So before we run out of time, I just
50:44
want to go back to two things. You've said so much that you know
50:46
that we could spend three hours just going over what you've talked about, but
50:52
just just so that people don't forget. So let's go back first to the
50:58
fruit tast So I just want to be or people know that they can eat
51:00
fruit, just don't eat a lot of fruit and don't make that the primary
51:06
focus like they were. Where was the time Remember when people were fruitarians and
51:09
they were eating only fruit and that was totally devastating to health. So so
51:15
just you know, recognize it to cut back on the number of fruits that
51:21
you eat in a day, but don't give up eating fruit. The second
51:23
thing you said on the oils or on the fats is to be sure to
51:29
cut out all the facts that are not that are that are not poly unsaturated.
51:36
So you want you want to keep olive oil, avocado oil, coconut
51:40
oil, butter, which is if it's grass fed butter, all the better,
51:46
or grass fed meats, wildfish, you know, nice salmon, tuna
51:52
and things like that settee, fish, sawdines, all that type of thing,
51:55
all very very healthy and um you know the transfer that sort the thing.
52:00
And I understand the government is trying to get trans fats out of our
52:05
system. But you know, most frozen foods and you know these frozen pizzas
52:10
and all these type of things. They have a lot of cookies, cakes,
52:15
you know, all these things, they have a lot of trans fats
52:16
in them. And you know that's that's what you wanted to stay away from.
52:22
But isn't one of those that are dangerous. Isn't that palm oil that
52:27
you see in a lot of the big goods that Yeah, yeah, I
52:32
think that that's not necessary. A healthy a healthy fat either. But again,
52:37
I you know that's so important, eating healthy fats, and I think
52:43
people have to get it. You know, everyone knows their cholesterol level,
52:45
but you know who knows what they're fasting sugar is, which is far more
52:49
important. You know, you need to know you're fasting. If you look
52:52
at your fasting sugar and you're fasting, incident, you can multiply those and
52:55
divide by four or five. Only about ten percent center people have their homer
53:00
I artists that's an insulin resistant test, and you want to have that below
53:06
one point two. Most people are above that eighty eight percent. Ninety percent
53:09
of Americans are above one point two. Under one point two means you have
53:15
metabolic flexibility and insulin sensitivity, which is what is natastic and what to call
53:20
well the homer I homer I artists. And it's very easy. You could
53:25
look it up in people's you know what's up or whatever I mean on the
53:30
Google. But to include that in any blood work, yeah, you should.
53:35
You you want to multiply the fasting sugar person's fasting sugar, buy the
53:39
fasting insulin, and divide the product by four oh five and hopefully you're less
53:45
than one point two. Okay, that's very helpful. Well, the other
53:49
thing that I wanted to mention is on cholesterol. So people should understand that
53:52
your absolute cholesterol, which is what you know a lot of doctors based there
53:59
there pharmaceutical stating drug prescriptions on. It's not the measure of predictive of heart
54:07
disease. So, as Graham mentioned, if you have cholesterol over two hundred
54:13
let's say two twelve, which is what mine was last time, you shouldn't
54:16
panic because it's really your the size of your particles, and that's where the
54:22
LDL, the low density of that bow proteins come in. I don't want
54:25
to take you away from what you would say about this gram, but I
54:30
just want to keep it simple for people to understand that when you go to
54:34
your doctor, make sure that they're doing the tests that measure the particle size
54:40
and also that you get your ratio your LGL to HL. High density is
54:45
a good and low density is the bad. So can you just add to
54:50
that to I mean, what's much more important is your triglycerides. Triglycerides,
54:54
which is the other blood fit which that makes in your lipid panel is six
54:59
times times more predictive of heart disease than cholesterol. And looking at your triglyceride
55:05
HDL ratio, if that's above two, you have you're a little in trouble.
55:09
And if it's a you know, I see most people with diabesity,
55:14
they're triglyceride HDL ratios are very much close to three or even a lot higher
55:19
than three. So triglycerides are the key thing. The other thing, I
55:23
you know, I've never seen any convincing evidence that putting a woman on a
55:29
statin has ever increased to life by you know, one year or six months.
55:35
So now I think, yes, if you've had a heart attack and
55:37
you've had a stent, and as these people, yes, and you're probably
55:43
taking it not to your cholesterol. You're taking it because statins have some anti
55:46
inflammatory effect which they will more recently recognize. But you know, for people
55:52
who haven't had a heart attack, you can easily correct everything just with a
55:57
decent, well formulated key to diet. In fact, studies from the Verta
56:00
Group show that twenty four out of twenty six of your risk factors go down
56:06
when you implement a well formulated keto diet with a little intimate and fasting.
56:10
So you know, I think people are just you know, terribly excited about
56:14
the cholesterol, and for me it's a non issue. Okay, Well,
56:19
I just got the signal that we've we've run out of time. But I
56:23
just want to be sure to tell people how to reach you, Graham,
56:27
because I know you're doing so much good work, and you know there are
56:30
people that could consult with you long distance if they want to. I'm sure
56:36
you could do it on zoom right with some people that yeah, we do
56:39
a lot of We do a lot of that, and we've got some good
56:43
health coaches as well as you know, certified docs. So you know,
56:46
we obviously want to reinvent healthcare in a way which is really our mission is
56:52
democratize healthcare. I mean, that's really our mission. So could you just
56:55
give us the correct contact info the people can reach to reach out to you
57:01
and I. The easiest is just probably Graham at um LB five one hundred
57:09
dot com. Greg your ah Am LB five one hundred dot com. Okay,
57:16
so, LB five one hundred is the name of your new enterprise right
57:22
that you're you're working on, and that means live below one hundred, which
57:27
live below five to live beyond one hundred. That's how we get the LB
57:31
five one hundred dot com. That's that's about and we are doing it for
57:37
probably four or five years in many countries outside the US, but we're just
57:40
opening in a number of centers throughout America at the moment. Okay, good
57:45
so, And I know that your CEO has contacted me from Australia. Her
57:52
name is Sarah, and she and I are working on some incentives for the
57:58
viewers today. We'll put that on my website. I don't want to get
58:00
into the complicated part of that, but it's very generous and I know that
58:06
people will be interested. So please check my website under Michelle Recommends, and
58:12
that's at www dot Angeles and timeless dot com and that would be under Graham's
58:19
our podcast today, which will probably air in another maybe week or so.
58:24
So I want to say goodbye to everybody, and thank you so much,
58:28
doctor Simpson. We've had an amazing discussion today, you know someone no,
58:34
thanks very much for inviting me. I love to get some of the new
58:37
new information out to people. Well. Information is power, right, and
58:43
you currently have a powerful message to tell to the world. So I have
58:47
a wonderful day everybody, and don't forget to subscribe and like the podcast and
58:53
like this channel if you if you could, and we will see you again
59:00
in another week. Take care. I bite