720-ROCK2 Inhibition for Treatment of Liver Fibrosis
This research identifies ROCK2 as a critical driver of liver fibrosis, specifically appearing in elevated levels within the vascular endothelial cells and hepatic stellate cells of diseased livers. Scientists developed TDI01, a highly selective and potent inhibitor designed to block this protein’s activity and restore healthy vessel function. The study demonstrates that TDI01 successfully reduces scarring and inflammation in rodent and minipig models of metabolic dysfunction-associated steatohepatitis (MASH). Early human trials confirm the drug is safe and well-tolerated, showing favorable…
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