061-Hallmarks of response, resistance, and toxicity to ICB
This review explores the hallmarks of response, resistance, and toxicity to immune checkpoint blockade (ICB) in cancer treatment. It details various immune checkpoint molecules and strategies, including CTLA-4, PD-1, and emerging targets, alongside their clinical applications and associated adverse events. The text also thoroughly examines factors influencing ICB efficacy, categorizing them into host-intrinsic elements like tumor genetics, the tumor microenvironment (stromal and immune cells, metabolic status, microbes), and systemic host factors (gut microbiota, obesity, hormones). Finally…
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