PSYCH 019: Gene Mapping Investigations of Psychiatric Disorders
If multi-omics reveals layers of biological complexity, gene mapping attempts to locate patterns within that complexity. This chapter explores how researchers identify genetic contributions to psychiatric disorders - not through single genes, but through probabilistic associations across the genome.
In this episode, we examine approaches such as linkage studies, candidate gene studies, and genome-wide association studies (GWAS). These methods do not identify deterministic causes, but patterns of increased risk distributed across many genetic loci.
We explore the concept of polygenicity - the…
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