271-ELLA: Subcellular Spatial Localization Analysis
The paper introduces ELLA (subcellular expression localization analysis), a novel statistical framework designed to model and detect spatial variation of gene expression at the subcellular level within cells using high-resolution spatial transcriptomics data. ELLA utilizes an over-dispersed nonhomogeneous Poisson process and a unified cellular coordinate system to analyze diverse cellular morphologies and transcriptomics technologies, outperforming existing methods like SPRAWL and Bento in simulations. The application of ELLA across multiple real-world datasets—including mouse liver, mouse…
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