313-Whole Genome Doubling Remodels Ovarian Cancer Evolution
This research utilizes single-cell whole-genome sequencing (scWGS) and a novel evolutionary timing method, doubleTime, to characterize the impact of Whole-Genome Doubling (WGD) in high-grade serous ovarian cancer (HGSOC) across 41 patients. The analysis confirmed WGD as a pervasive and ongoing mutational process that greatly increases cell-to-cell diversity and chromosomal instability within tumors. Critically, WGD status dictates the innate immune response and phenotypic state of the cancer cells and their microenvironment. Tumors classified as WGD-low show an active anti-cancer inflammatory…
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