260-Taxonomy of Telencephalic GABAergic Neurons

Paper Talk · Nov 23, 2025 · 13m

This paper details a systematic and in-depth analysis of GABAergic neurons within the mouse telencephalon, integrating high-resolution single-cell RNA sequencing (scRNA-seq) with spatial transcriptomics (MERFISH). The study establishes a comprehensive, hierarchical cell-type taxonomy for these inhibitory neurons, charting their complexity across various regions and developmental stages. A key finding is that the organization of these neurons reflects both their spatial location and their embryonic developmental origins from subpallial progenitor domains. Furthermore, the research highlights…