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RNA Polymerase Reads 8-Base Genetic Code | Science News
Scientists have cracked a major biological code: they’ve taught RNA polymerase, the enzyme that reads DNA, to handle an expanded genetic alphabet of eight letters—doubling the natural four. Using high-resolution microscopy, researchers at UC San Diego watched the enzyme seamlessly recognize two synthetic base pairs, leveraging familiar signals to ensure accuracy. This breakthrough paves the way for engineering novel biological functions and therapies, including targeted cancer treatments. Even more impressively, the enzyme works with synthetic pairs lacking traditional hydrogen bonds, hinting…
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