1197-Nuclear MAP1B Regulates Neural Stem Cell Fate

Paper Talk · Jun 28, 2026 · 21m

Researchers have identified an abundant nuclear pool of cytoskeletal proteins within human and mouse neural stem cells, challenging the traditional view that these components function primarily in the cytoplasm. The study highlights MAP1B, a microtubule-associated protein that shuttles into the nucleus to interact with the BAF chromatin-remodeling complex, thereby influencing gene expression and cell fate. While cytosolic MAP1B supports the transition into neurons, its presence in the nucleus is essential for maintaining neural stem cell identity and ensuring proper brain development…