1414-CD23 Regulation of NKT17 Homeostasis

Paper Talk · Aug 10, 2026 · 18m

This study identifies CD23 as a critical internal regulator that maintains the balance of NKT17 cells by protecting their survival. Researchers discovered that a lack of CD23 selectively reduces the number of these specific immune cells and decreases their IL-17 production, which in turn lowers airway inflammation in asthmatic models. Mechanistically, CD23 supports the IL-7Rα-mTORC2-AKT signaling pathway to prevent cell death and sustain metabolic health. While deficiency in this protein impairs the development of the NKT17 subset, the introduction of exogenous IL-7 can successfully restore…