789-Hyperinnervation Inhibits Regeneration in Mammalian Skin

Paper Talk · Apr 13, 2026 · 22m

This article identifies a critical developmental shift in mammalian skin where the ability to achieve organ-level regeneration is lost shortly after birth. While embryonic wounds can fully restore complex structures like hair follicles and sweat glands, postnatal injuries typically result in scarring and a failure to regenerate diverse cell lineages. The study discovers that postnatal wound-specific fibroblasts (PWFs) drive an abnormal increase in nerve density, termed hyperinnervation, which acts as a fundamental barrier to the healing process. By secreting the factor CXCL12, these…