Pharma 29: Heart Failure - Supporting the Failing Pump

Clinical Deep Dives · Feb 2, 2026 · 1m

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This episode reframes heart failure as a syndrome of maladaptive compensation. What begins as the body’s attempt to preserve perfusion—fluid retention, vasoconstriction, neurohormonal activation—gradually accelerates damage and inefficiency. We explore heart failure therapy as a coordinated effort to unload the heart, interrupt harmful signals, and rest…