1716-Clonal Architecture of Newborn Mouse Forebrain

Paper Talk · Oct 28, 2026 · 24m

The paper present a comprehensive developmental atlas mapping the clonal lineage relationships and spatiotemporal architecture of the newborn mouse forebrain. Researchers utilized lentiviral barcoding combined with single-cell RNA sequencing and spatial transcriptomics to trace the origins of hundreds of distinct cell types across major brain regions like the cortex, hippocampus, striatum, thalamus, and olfactory bulb. The findings reveal fundamental organizing principles of brain development, demonstrating that glutamatergic neurons and astrocytes share regional origins while GABAergic…