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Dr. Mike Roizen: 90 Is The New 40 (How To Hack Your Longevity) | E72 · In Search Of Excellence

• 0:00
  Michael Roizen: There's a huge benefit to the childhood vaccines in preventing brain dysfunction, preventing organ dysfunction. And it's like winning the lottery, it's about a 40,000 to one shot. When you hit 90, you may be able to get to be 40 again, or you may be able to slow the rate of aging.
• 0:18
  Michael Roizen: So it's not improving, it's not lasting longer in your 90s, and hundreds and hundreds. It's saying your 30s and 40s are going to last a lot longer.
• 0:31
  Randall Kaplan: Thanks for listening to part two of my amazing conversation with Dr.
• 0:32
  Randall Kaplan: Mike Roizen, who has helped 10s of millions of people improve their health and wellness through simple lifestyle changes we can all make. If you haven't yet listened to part one of my amazing interview with Dr. Mike, please check that one out.
• 0:44
  Randall Kaplan: First, we talked about stress.
• 0:48
  Randall Kaplan: And you talked about the importance of having amazing friends and reducing your stress. You haven't talked about the downside. And you've mentioned the word assholes before removing assholes from your life. Can you just talk a little bit about that a little more and stress the importance of everything about how to eliminate assholes from our life?
• 1:08
  Michael Roizen: Yeah, I don't know of any study that really use that term. So in this since I'm a data nerd, or science nerd, let me stick with the science, which is that stress the major stressful life events are, someone dies in the family, you get sick, you're sued, you have financial problems, you have to take a new job, you move, they are the ones there are the 15 of them. nine or eight or nine of them are clearly financial. So we have all have stressful events. And you can say, having someone who is an asshole, if you will to you is a stressful life event if you perceive it that way. So stress isn't the event. It's your perception of it, which allows you to manage it and modify it. So my favorite story and it's way old study this was in about 1995 or six I was in this was Christmas Eve, in Chicago, at I'm blanking on the store now. But it was it was on State Street and Monroe in Chicago. People were in Chicago will know what store that is.
• 2:37
  Michael Roizen: But anyway, the store I went in there, and I had a bunch of gifts still to get. And I was in there with my son who was probably young at the time, he meaning a teenager. And they were just people throwing money at the clerk literally trying to get her to take money because it was one clerk and probably three rows store closed at five, this was 445. And so I waited to the clerk way till there was literally no one there was 515 or something. And I said, this has to be awful stressful for you. And she said, Are you kidding? This is the best day of my life. I said, What do you mean, she said, look at all those men trying to get to me.
• 3:24
  Michael Roizen: So she had reframed the situation into something positive. And something that to me would have been very stressful. All those people waiting for me, she looked at it as a very positive thing. So how you look at something really determines and so you can modify that. And I've taken that to heart and practice. So I practice a stress management technique is just deep breathing, putting a finger on your belly button, and doing a double breath in twice a day and getting your belly button to move out as you do it. My belly button moves out. I know I'm breathing correctly, but I'm focusing on my breathing and nothing else. And I do that 10 breaths morning and night. And so that's my stress management.
• 4:11
  Michael Roizen: Someone cuts me out often in traffic, I put up my finger, someone does something else I go my finger goes to the belly button, and I just deep breathe through it.
• 4:23
  Randall Kaplan: So I've talked about flu shots and a lot of your research and how regularly taking flu shots over the years increases your life expectancy.
• 4:30
  Randall Kaplan: I haven't heard a lot.
• 4:34
  Michael Roizen: You really paid a lot of attention to that talk.
• 4:37
  Michael Roizen: I'm impressed. Thank you.
• 4:40
  Randall Kaplan: You're welcome.
• 4:40
  Randall Kaplan: But you haven't talked a lot about COVID testing. There's a tremendous amount of controversy right now among the effectiveness of COVID test the safety of COVID test. Can you talk to us about
• 4:51
  Michael Roizen: how that test you talking about the vaccine?
• 4:55
  Randall Kaplan: Sorry, I apologize. Yes. The vaccine itself. There's a lot of controversy. See over the COVID vaccine, a lot of people worry about its effectiveness and then health issues risk issues, especially because they've only been around for a couple of years. And we've seen so many vaccines throughout the years, not worked out. Well, over the long term, people just don't know, there's not a lot of tests going back that far and not a lot of data. Talk to us about
• 5:23
  Michael Roizen: that. Let me go and talk about vaccines in general, because I have very strong opinions about vaccines in general, and maybe different opinions about COVID 19 boosters, so I'm gonna come to both. So I apologize, and I don't want to turn any of your listeners off, memorize and I interviewed over 150 people on every side of the vaccine issue related to childhood vaccine schedule, and believe it probably could be changed without harm, but there's a huge benefit to the childhood vaccines in preventing brain dysfunction preventing organ dysfunction. And it's like winning the lottery. It's about a 40,000 to one shot. Well, when we publish this and different vaccine schedule, that was Dr.
• 6:14
  Michael Roizen: Greene's vaccine schedule that we thought was just as valid as the CDC one, you know, no one would talk to us again, the people on the right, wouldn't it be boring, the left wouldn't, but in fact, the vaccines, it's about a 40,000 to one, and you'd put down $1. To win 40,000, if the worst that you could happen is you'd lose the dollar. That's what it is in getting the childhood vaccines and maybe you want to pace them out a little more, but they still have a huge benefit in COVID-19 initial vaccination, and probably the initial booster had that same value for people over the age of 50, or with comorbidities. But the more recent if you've gotten two boosters, the third and fourth booster in the Cleveland Clinic own employee database, inhibits your ability to prevent COVID-19. So it is as though you're getting an allergy shot if you get more than four boosters. At this time, meaning that allergy shot is something to decrease your reaction to the allergen. Well, that's the same thing that's happening, you're decreasing your reaction to your prior immunity. So it's actually turning on IO for a different immune response than would fight the COVID-19. So right now until at least August or September, we're in limbo and saying probably not boosters right now, unless you have long COVID. And I'll come back to that in a second. And probably in August and September, we at least I would advocate we go back to a traditional vaccine. If the data that we've seen so far holds that traditional vaccine booster would be in something like Novavax is vaccine booster, which is a traditional rather than an mRNA vaccine. Now, that isn't that quiz that isn't the official position of the Cleveland Clinic. That's just mine. A few of the people on the Scientific Advisory Board have longevity playbooks, looking at the data and analysis of it. Now under 30, under 50, or without caught and without comorbidities, the the benefit to risk ratio is much closer.
• 8:56
  Michael Roizen: And in kids, the real benefit is preventing them transmitting it to the elderly, not a benefit to themselves. Except for long COVID. Why do I say except for on COVID? I'm scared of long COVID Because if you look at the Spanish flu from 1917 to 19, it traveled up the olfactory nerve to the basal ganglia just like this in the viral particle analysis and caused most of the Parkinson's disease in the 50s 60s and 70s. It was a long term effect of that Spanish flu.
• 9:30
  Michael Roizen: COVID-19 has the same pathway, up the olfactory nerve your smell nerve into your back brainstem and basal ganglia and that's where the viral particles come. We know that if you haven't gotten vaccinated and have long COVID Getting vaccinated, about a third of the people get rid of one COVID The other two thirds So, we don't know the answer for long COVID yet, but that's my fear. And so what do I have I gotten? Yeah, I've gotten the actual two shot vaccine and three boosters. And sometime in August or September, I may get the next booster if the Nova Vax vaccine data folds as it looks like it is now. So I'm scared of, of some of the side effects of the vaccine. But as you know, I'm an old guy, and I don't have comorbidities that I know, but I'm an old guy. And so I'm scared of the inflammation. And then we go back to the flu vaccine, you get the flu vaccine 10 years in a row, you decrease risk of dementia by 40%. As opposed to people who get it irregularly during that period, or and not consistently every year. That's due to the inflammation that the flu itself causes that you dampened down if you get the flu vaccines.
• 11:08
  Randall Kaplan: So let's hit another big one. And I think this is common sense to most people, but you have made some recommendations with respect to food, and how food eating the right types of food can increase our longevity as well. And you you talk about poisoning your body. So let's talk about some of your recommendations. I've never heard anyone to take a tablespoon of virgin olive oil before that one struck me as a kind of strange when I want to whip that I want to put it to a tablespoon of Virgin Island No,
• 11:45
  Michael Roizen: it's It's whether you cook it with it or use it in salads, or put it on bread. It's not taking it direct, although some people do take it direct if you're in Italy. And in Sardinia, they do take it direct but in fact, for most people it is on something or in something else. And that's the data you get the same benefit. Large Spanish study looking at breast cancer risk looking at cardiovascular disease risk, decreased both of those by over 30%. By that half tablespoon a day.
• 12:21
  Randall Kaplan: There are so much more on the food side that I want to go into. You have this amazing quote which says that you would want to marry someone who is trying to kill you every day. So let's go into some of the more detailed recommend recommendations that you have.
• 12:35
  Randall Kaplan: And just tell us about what you're talking about there. And so we all love French rules. By the way, we all love french fries,
• 12:44
  Michael Roizen: food is relationship. And you wouldn't marry someone who was going to try and kill you every day. You shouldn't eat food that's trying to kill you every day, and the food that's trying to poison you every day. Simple sugars, added syrup, simple carbohydrates, red meat and processed red meat.
• 13:02
  Michael Roizen: Those data are very clear.
• 13:02
  Michael Roizen: Whether you look at the interventional animal studies or the epidemiologic human studies.
• 13:13
  Michael Roizen: We know that simple sugars feed cancer, simple sugars increase your risk of fat in your muscle, which increases your risk of insulin resistance and all the other problems that causes and we know that process red meat and red meat actually change when given with saturated fat actually changes the genes of your bacteria inside you to produce inflammatory proteins.
• 13:39
  Michael Roizen: So you'll see we've I've said a lot about inflammatory inflammation and about proteins and inflammatory proteins.
• 13:47
  Michael Roizen: Stress Management being the most effective thing that we know that turns those off. But we know that what turns a mind is in fact, red meat, processed red meat, simple sugars, added syrups and simple carbs. So we say there's no reason to not find food you love. There are tons of food. I love salmon. I love avocados. I even love extra virgin olive oil and some whole grain bread and those things and on salads and those things are healthy. So eat things that you I love tomato sauce made with olive oil. Those things are healthy. I just did you know you can have them in virtually unlimited quantities as long as you within that not getting overweight, et cetera. But those are things you can love and love you back.
• 15:34
  Randall Kaplan: Is it okay to eat some of these things in moderation? I just had some fried chicken a week ago and when I started dating my wife nine or 10 years ago, I love fried chicken. It's so good.
• 15:43
  Randall Kaplan: I've always loved and said hey, that's just cholesterol putting that in your body when I have chicken parm and I want it. I love Steak. I've talked to my doctor, I have a executive concierge doctor as well. And we talk a lot about these things.
• 15:59
  Randall Kaplan: Can you eat these things in moderation? And not have it affect how long you live? Or are you saying cold turkey,
• 16:10
  Michael Roizen: it depends on what you call moderation. So four ounces of Redmi a week, assuming nothing else in that category, doesn't change genome functioning of the bacteria, so much as to cause inflammation in you. But eight ounces twice a week or one big steak, we'll do that. Even if all you have it is once every week. So that's the risk, you can measure what it's doing to you by measuring your TMA o level. And if your tml level is above 1.6, then you know you shouldn't be having that red meat. So you can find out because there's some people whose bacteria don't react that way, we don't know why. The as far as fried chicken, getting the airfryer it apparently tastes the same. And you don't have the problem with fried deep frying is the fat in the chicken gets replaced by the fat in the deep fryer. So you're getting trans fat, and you're getting fats that aid you in your chicken. But if you do it in a airfryer, it doesn't get those fats. It does oxidize some of the fat in the chicken because of the heat that's generated.
• 17:40
  Michael Roizen: But in fact, it probably is fine. As opposed to the deep fried bath and deeper. And you know, fish that is deep fried is not fish.
• 17:52
  Randall Kaplan: He clarify what you mean by simple sugars because I think there's a lot of confusion, good sugar and bad sugar. I have a smoothie each morning and I load it with fruit. I put fruit in their milk, little coconut water and some protein powder. And I love it is that bad for you? Or what we
• 18:11
  Michael Roizen: don't think so you're not getting you're not putting sugar in directly.
• 18:13
  Michael Roizen: You're the fruit, the sugar and fruit is generally bound to fiber and is not as easily absorbed. And there may be two sugars, there's emerging data on both tree loss and allulose that they may impede your absorption or the speed of absorption of the other sugars. So it's anything that ends in an OC is a simple sugar maltose, lactose, glucose, sucrose, etc dextrose.
• 18:47
  Michael Roizen: Whereas in syrup, you know what a syrup is. So syrup, it tastes sweet at the syrup. So those things feed cancers and so, but in at four grams a day, four grams per hour, 20 grams a day, you probably find your body handles it fine, as long as you don't go more than four grams of added sugar in any hour. So moderation is fine there.
• 19:22
  Randall Kaplan: Obesity is one of the biggest health risks in the United States actually in the world heart disease. I think it was number one killer of people in the world. He talked to us about brown fat versus white fat ozempic These new diet pill diet shot drugs that reduce weight and fat reduction surgery, liposuction and the effectiveness of all of this and where do you stand on all of this?
• 19:47
  Michael Roizen: What we've learned is that obesity, especially middle obesity that is around your waist. That's why we say your waist should be half your height. When measured at the belly button with you sucking in that fat causes inflammation again in you.
• 20:03
  Michael Roizen: That's white fat, but the white fat came from mother fast as the brown fat brown fat uses calories when you're young.
• 20:12
  Michael Roizen: under the age of six months.
• 20:16
  Michael Roizen: It's what keeps you warm and your organs warm when your mom isn't swaddling you full time.
• 20:19
  Michael Roizen: Wouldn't it be great to change that weight fast in the mother fat and regress it to brown fat and then you'd be able to stay thinner. And one of the things that the GLP ones do is stop cravings. But another that they do apparently is convert some of the weight fat to bronze fat and increase metabolic rate. In addition to causing the stomach nrmp is fast, so you don't feel as hungry. So, three different effects of the Mon journos a DEXA. And ozempic, we'll go over. And I think they're very useful for some people, I have a number of patients who literally would think food 24 hours a day, that is, even when they're sleeping, they're dreaming about food that they're going to have the next day. And that gets on and they can't think of anything else, you know. And so, for those people, these drugs are tremendously beneficial. They don't cost any place near what they're being sold for. Even wholesaled for to make. So I, I think we will get to the point where this really stops drug abuse, that really stops alcohol craving, if it really stops food craving, we're going to have that in a lot more people and save the country a ton of money in medical costs, and save each of us a ton of shortening of disability free lifespan, so we're gonna get the live longer, younger, healthier. If this if these really are as good as they seem to be, and we've only had them for a couple years now,
• 22:23
  Randall Kaplan: I have a bunch of friends who are taking it right now. And they tell me it's very painful. And they also said, there's a lot of side effects. What do you think about the side effects? Is the risk reward worth it for people who are not tremendously obese, but maybe they need to shed 10 or 15 pounds to just look tremor and feel better about themselves?
• 22:42
  Michael Roizen: We don't know the answer to that. I can tell you that, that. If they're if they have an infinite craving, and if they're really suffering from a craving, it may well be worth the risk. But we don't know the long term risks. These are only been around in clinical trials for two years. So we really have no data on do they change brain functioning long term? Are they okay for teenagers, we don't really know any of that data. So I just be speculating in the speculation is for people who can't do it any other way and have an infinite craving, whether for alcohol or opiates, or food, these these seem to be very effective.
• 23:32
  Randall Kaplan: Every year, there seems to be something new with respect to our health and how we can take care of our bodies better. Can you talk to us about the effectiveness of a hot sauna in a cold bath, and all the rage right now the effectiveness of a cold plunge.
• 23:46
  Michael Roizen: We have much better data on the hot sauna in populations due to their presence in Finland and even British Columbia and some of the Canadian areas where it was worried they would increase that Asana would increase heart disease, increased stroke risk and people who were at risk and they decreased it. So it appears that both hot and cold work through the same mechanism.
• 24:13
  Michael Roizen: Turning on heat shock protein, that is an abnormality going up or down in temperature seems to do the same thing. And by the way, red white seems to have a similar benefit, but through a different mechanism, increasing ATP production. Nevertheless, what I'm saying is cold and hot work through each shock protein, at least in animals and in the human studies so far. And that preserves proteins from yelling a into a abnormal shape. And that apparently keeps you younger longer.
• 24:58
  Randall Kaplan: I think all of us have been taught that taking vitamins every day will improve our health and prevent illness.
• 25:03
  Randall Kaplan: And a lot of us have also been taught you should take some vitamin C and sometimes vitamin D and fish oils. Can you talk to us about their actual effectiveness and prolong your life? And also we're creating factors into that.
• 25:15
  Michael Roizen: Yes, there if you look at that 53 or so that we've been asked to analyze on in the longevity playbook. And we have a library that goes through each of them with a summary. And then within lay language and then all the data for physicians to look at or practitioners to look at for you to look at if you want but there are 15 of the 53 have enough data in humans on benefits that we think most people should talk to their practitioner about whether they're beneficial for them One of those, one of them that we were surprised with was creatine. Creatine is a protein that's used in the younger set meaning 15 to 35, to try and look like Arnold does. But in fact, when you look at the data they have been used in old people in do prevent frailty, muscle wasting. And at the same time, because they looked at the side effects, what does it do to mental functioning, it improved mental functioning. So that's one way you might take 4000 milligrams four grams a day.
• 26:34
  Michael Roizen: It's a I get it in a powder at on the internet, it's $36 for I think four bucks for a month's worth of stuff. So it's really quite cheap nine bucks a month, and seems to have benefits for decreasing brain dysfunction.
• 26:55
  Michael Roizen: But anyway, there are about 15 of those that do it. I unfortunately, Randy, have a time limit, I've got to run someplace. So can I can Can you forgive me for not discussing all of these in detail and just telling you, they're all at the longevity? playbook.com?
• 27:19
  Randall Kaplan: Can we really live to 120 years old? And do we really want to
• 27:24
  Michael Roizen: force society, we need to, and with 14 research areas on the mechanism of aging, that have reversed age in at least two animal species each, it looks like that with 14 shots on goal with an 80% probability we'll be able to live a lot longer younger, and this is really emotionally difficult.
• 27:52
  Michael Roizen: It's saying, when you hit 90, you may be able to get to be 40.
• 27:56
  Michael Roizen: Again, or you may be able to slowly rate of aging. So it's not improving, it's not lasting longer, your 90s and hundreds and hundreds, it's saying your 30s and 40s are going to last a lot longer. From a society standpoint, we don't producing enough kids, thank you for five, but most people, the fertility rate is in the United States is now at a very low level, I think it's under one seven, you need to three for every woman in the childbearing age to repopulate society to two to two, three, were at one seven, believe it or not, Korea has just gone below one. China will be half the size it is in 2100. population wise if nothing changes from their rate of fertility. So that means we won't have enough young people to support those who are retired. Give you the example in France they had in 1960, they had four workers to support every retired person, they're now at about 1.4. That's why they're having the fights over 62 to 64. This is happening throughout the world that isn't just the United States or just in Japan or just in France, or just in Italy, it's throughout the world. So we need longevity and people to extend their most productive times from 25 to 65, or 20 to 65 from 40 years of working age to 60 years gives us 50% more productivity 50% more tax revenue 50% More Medicare and Social Security revenue. So those funds won't run out the way they're scheduled to run out. If we do get longevity, we think there's at least an 80% probability with 14 shots on goal that you're going to be able to live a lot longer and a lot younger with a lot less disability, if you choose to do so.
• 30:06
  Randall Kaplan: I think most people today are thinking there's no way I want to live to 100 years old, I'm going to be at home. And my quality of life is not going to be good.
• 30:16
  Michael Roizen: But it's different. It's living, it's getting back to 40 again, so think of yourself as a I don't know how old are you Randy? I'm 54. So think of yourself as a 35 year old again,
• 30:29
  Randall Kaplan: I do mental everyday
• 30:32
  Michael Roizen: with the experience you've got now. So in the fun you have now and that and so in the animal models, the mice get younger their muscles function as though they're three the if you will the equivalent of 30 to 45 to 45 year old humans their pancreas gets rejuvenated their brain starts functioning, if you will, as if they were able to do the the speed of processing they had when they were younger. So the whole body has a chance of getting younger, I think there's at least an 80% probability of it. And that's why I really wrote the book. And that's really why the longevity playbook site is there. It's to help people curate and understand what will happen, plan for and get there in great health. So they actually have a disability free longevity. So they really can be functionally the way they were when they were 35 or 45. Again,
• 31:40
  Randall Kaplan: so the last question is, is it just been absolutely fascinating, and I just love talking to you, I love your I love your talk to the conference. The website, by the way, is incredible. And so is the book, which I've read the issue, I think, for most people, Dr. Mike is there's so many things on the checklist, and people are not going to go to the website every day, they probably won't go to the app every day. Is there just a simple eight by 11 checklist that we should be looking at every day to make this easy on us? And is this really doable or practical to do all these things?
• 32:13
  Michael Roizen: The answer is, you should only do what you like doing and what you love doing.
• 32:17
  Michael Roizen: And that's the point you can find a whole bunch there. There are many choices, do some things you like and if you like it then add on. So that's how I did it, you know, in other words, I never knew the dangers of red meat and processed red meat and that they were changing the bacteria functioning inside my gut the way they are. I never knew that, you know, if you will, there was a benefit to starting a statin early and getting control of my cholesterol. I never knew that half a tablespoon of extra virgin olive oil a day, or that smelling for different smells.
• 32:57
  Michael Roizen: Was that important or that?
• 32:57
  Michael Roizen: cooked tomatoes were that important. But those are easy, right? That doesn't take much extra time. And so I've added on but no one can no one's perfect.
• 33:13
  Michael Roizen: And so there's no, there's no you know, this is not to say you shouldn't be perfect. But the DOI you by the way the deal the subscription. Once you get through the free trial, if you want to subscribe, it's 200 hours for the for you for a year. But you get a friend and the friend is the biggest boost whether it's your spouse or another person. That's the way you stay younger and why you encourage each other to do things and try other things that may be fun for you,
• 33:44
  Randall Kaplan: Dr. Mike, again, thank you for being here. I hope everyone's gonna go out and buy your book. We're gonna put all the links in the in the podcast and in a video that we're gonna put on YouTube. You've truly influenced the lives of 10s of millions of people and the world is better for it. So I appreciate you being here.
• 34:01
  Randall Kaplan: Thanks for being on my show.
• 34:04
  Michael Roizen: Thank you Randy.