566-The Landscape of HumanTuberculosis Granulomas

Paper Talk · Feb 28, 2026 · 15m

This research utilizes multiplexed ion beam imaging (MIBI-TOF) to construct a spatial atlas of the human tuberculosis (TB) granuloma, revealing how immune cell organization dictates disease progression. By analyzing archival tissues, the authors identified eight distinct microenvironments where specific myeloid and lymphoid cells interact, highlighting a specialized myeloid core characterized by immunosuppressive proteins like PD-L1 and IDO1. Interestingly, while these regulatory markers are prevalent in active lesions, the typical T cell exhaustion seen in cancer is absent, suggesting a…