1644-Endothelial Nanovesicles for Targeted Ischemic Rescue
This research introduces CeO2-NMUiECs, a sophisticated dual-targeting nanotherapeutic designed to treat ischemic diseases by repairing damaged blood vessels. Scientists engineered these nanovesicles from iPSC-derived endothelial cells and armed them with antioxidant ceria nanozymes to survive the toxic, oxygen-depleted environments of injured tissues. The platform leverages a natural homing mechanism to navigate directly to sites of injury, where it simultaneously neutralizes harmful reactive oxygen species and delivers pro-angiogenic proteins to stimulate vessel growth. Rigorous testing…
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