269-MAGE: Generative AI for De Novo Antibody Design
The article details the generation of antigen-specific paired-chain antibodies using large language models (LLMs). The authors, Wasdin et al., introduce MAGE (monoclonal antibody generator), a sequence-based protein language model fine-tuned to efficiently design diverse human variable heavy- and light-chain antibody sequences targeting specific pathogens. MAGE utilizes an extensive antibody-antigen sequence database and demonstrated its capability by generating functional antibodies with experimentally validated binding specificity against SARS-CoV-2 (RBD), H5N1 (avian influenza), and RSV-A…
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