487-Peripheral Glia Orchestrate Early Immune Responses

Paper Talk · Feb 8, 2026 · 16m

Injury-activated peripheral glia form a pro-reparative niche essential for skin healing. These repair glia recruit macrophages via the CCL2-CCR2 axis, which in turn drive fibroblast proliferation and myofibroblast transition. Glial depletion impairs this immune-fibrotic crosstalk.

References:

Stierli S, Salas-Bastos A, Micheli S, et al. A peripheral glial niche orchestrates the early stages of skin wound healing[J]. Cell Stem Cell, 2026.

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