1355-Diet–Microbiome Synergy in Immunotherapy Efficacy
This research explores the paradoxical link between obesity and improved immunotherapy efficacy, specifically focusing on how the diet–gut axis drives these clinical outcomes. By testing various nutritional models in mice, researchers discovered that obesogenic diets cultivate a distinct microbial ecosystem that enhances sensitivity to immune checkpoint inhibitors. The study identifies Lactobacillus johnsonii as a key bacterium that interacts with specific dietary fats to boost anti-tumor immunity through the production of aromatic amino acid metabolites. Findings demonstrate that switching…
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