1386-Modular In Vivo Antibody-ADC Click Therapy
Researchers have developed a modular therapeutic platform called antibody-ADC click to overcome the limitations of traditional cancer treatments. By using bioorthogonal chemistry, clinicians can sequentially administer two different components that chemically bond directly inside the body to create a powerful, multi-targeted complex. This method significantly improves drug internalization and tumor uptake, especially in heterogeneous tumors where target proteins are unevenly distributed. Experimental results show that this approach effectively reverses drug resistance in models that were…
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