488-Neddylation: Link Between Neuronal Aging and Alzheimer's

Paper Talk · Feb 9, 2026 · 16m

Researchers used CRISPR screening to identify neddylation as a vital regulator of neuronal aging. Blocking this pathway in stem cell-derived neurons triggers senescence, DNA damage, and proteostasis failure. These age-related hallmarks drive Tau pathology and cell death.

References:

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

Saurat, Nathalie et al.Cell Stem Cell, Volume 31, Issue 8, 1162 - 1174.e9

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