631-Chemotherapy-Induced Tumor Immune Evasion
This research reveals that chemotherapy unintentionally triggers immune evasion in liver metastases by reprogramming resident Kupffer cells into a suppressive LEPR+ state. This transition is driven by tumor cells that, when damaged by treatment, release cGAMP to activate STING-ID1 signaling within the liver’s immune environment. Once differentiated, these LEPR+ Kupffer cells infiltrate the tumor and utilize MerTK-dependent efferocytosis to clear away signals that would otherwise activate the immune system. This process effectively hides the cancer from cytotoxic T cells, leading to treatment…
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