Micro 46: Picornaviruses
This episode explores the picornaviruses, a large family of small, non-enveloped, positive-sense single-stranded RNA viruses. Drawing from Murray’s Chapter 46, it examines how genomic efficiency enables extensive clinical diversity.
The family includes:
* Enteroviruses (poliovirus, coxsackieviruses, echoviruses)
* Rhinoviruses
* Hepatitis A virus
The replication strategy is direct and efficient: the positive-sense RNA genome functions immediately as mRNA upon entry into the cytoplasm. Translation produces a single polyprotein that is cleaved into functional viral proteins.
Clinically…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.