585-Drivers of Gastric Cancer Response to Immunochemotherapy
This research article investigates biomarkers and cellular ecosystems that influence how gastric cancer patients respond to perioperative immunotherapy and chemotherapy. By analyzing data from the NEOSUMMIT-01 clinical trial, the authors identified specific genetic factors, such as HLA-B and LRP1B mutations, that serve as predictors for treatment success. The study categorizes the tumor microenvironment into five distinct ecotypes, ranging from immune-active zones that favor recovery to immunosuppressive regions that resist therapy. A critical discovery involves APOA1+ tumor cells, which…
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