283-Translational Control of Cellular Stress and Aging
This is a review article from Nature Cell Biology that systematically explores translational regulation in the context of cellular stress biology and aging. The authors focus on how three age-associated stressors—loss of proteostasis, oxidative damage, and dysregulated nutrient sensing—modify protein synthesis. The text details the specific molecular mechanisms by which cells sense these stresses and implement corresponding adaptive or, at times, deleterious translational programs, such as activating the Integrated Stress Response (ISR) or inhibiting mTORC1 signaling. Ultimately, the review…
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