955-ProAPOBEC: Enhanced in vivo RNA Base Editing

Paper Talk · May 12, 2026 · 23m

This research article introduces CU-REWIRE5, a pioneering RNA base editing platform that utilizes AI-assisted protein engineering to achieve precise genetic modifications. By fusing programmable PUF proteins with engineered cytidine deaminases called ProAPOBECs, the researchers expanded the targeting range to include previously difficult sequence contexts like GC, CC, and AC motifs. The study demonstrates the platform’s therapeutic potential by effectively lowering cholesterol levels in mice and reversing autistic-like behaviors in a disease model. Unlike permanent DNA editing, this…