1091-Human Sinoatrial Node-Cardiac Plexus Assembloids
Researchers have developed a sophisticated tri-assembloid model that mimics the human sinoatrial node (SAN) and its complex interaction with the autonomic nervous system. By integrating human pluripotent stem cell-derived pacemaker organoids with cardiac plexus and atrial organoids, the study successfully recreates the electrical conduction axis and neural regulation of heart rate. This platform allowed for the discovery of a specific PSAP-GPR37 signaling pathway that is essential for the functional maturation of pacemaker cells. Furthermore, the model serves as a powerful tool for disease…
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