719-OXGR1: A Therapeutic Switch for Rosacea Erythema

Paper Talk · Mar 30, 2026 · 22m

Researchers have identified α-KG as a key metabolite that naturally combats the pathological vasodilation and erythema associated with rosacea. By activating the OXGR1 receptor in vascular smooth muscle cells, this metabolite triggers a signaling axis that promotes vasoconstriction and reduces skin redness. Detailed cryo-EM imaging revealed a unique bipartite-acid pocket within the receptor, explaining how it recognizes specific acidic molecules like α-KG and itaconate. Using these structural insights, the team developed A-1, a highly selective and potent synthetic agonist that mimics the…