1009-The New Era of De Novo Protein Design
This review article examines the evolution of de novo protein design, highlighting a significant transition from physics-based models to deep-learning-powered methodologies. The authors describe how advanced tools like RFdiffusion and ProteinMPNN allow scientists to build entirely new protein structures from scratch rather than modifying existing ones found in nature. By leveraging generative artificial intelligence, researchers can now create sophisticated molecules to address modern challenges in medicine, sustainability, and technology. The text outlines successful milestones, such as the…
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