Urolithin A vs Inflammaging: The Liver “Brake” Protein That UA Protects (NR77)
Aging isn’t just time, it’s immune balance drifting out of control, and one of the most consistent signatures is inflammaging: chronic, low-grade inflammation that never fully resolves. This Deep Dive breaks down a mechanistic paper proposing that urolithin A (UA), a gut-derived metabolite linked to mitochondrial quality control, may protect the aging liver by stabilizing a key anti-inflammatory regulator: NR77 (NR4A1).
Instead of claiming UA “reduces inflammation” in a generic way, this study argues something sharper: aging-like stress increases MDM2, an E3 ubiquitin ligase that tags NR77…
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