1703-Mechanically MSCs Enable Tumor Radiotheranostics
The reviewed literature introduces the Stiffness-responsive MSC-Assisted Relayed tumor-Targeting (SMART) platform, an innovative therapeutic and diagnostic approach designed to overcome the lack of molecular targets in challenging cancers. By engineering mesenchymal stem cells (MSCs) with a mechanosensitive circuit driven by YAP/TAZ, the system successfully translates the physical stiffness of the tumor microenvironment into the expression of actionable synthetic biomarkers like PSMA. This programmable cellular strategy effectively "tags" previously untargetable tumors in situ, enabling…
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