1575-Stem-like Lymphoid Niches in HCC Immunotherapy
Researchers have identified a specialized immune environment in hepatocellular carcinoma called stem-like lymphoid niches (SLNs), which are primary predictors of successful immunotherapy outcomes. These unique structures are defined by the spatial interaction between CD70+ type 2 innate lymphoid cells (ILC2s) and progenitor exhausted T (Tpex) cells, which maintain the immune system's ability to fight tumors. The study reveals that the bacteria Bacillus cereus plays a crucial role by secreting PI-PLC, an enzyme that triggers the release of the cytokine IL-33 from blood vessel cells. This…
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