247-Remodeling Cold Tumors for Immunotherapy

Paper Talk · Nov 20, 2025 · 20m

This review addresses the major challenge in cancer immunotherapy posed by "cold" tumors, which resist treatment due to low immune cell infiltration and an immunosuppressive tumor microenvironment (TME). The authors meticulously examine the molecular and cellular mechanisms of this resistance, categorizing them into three "Cs": camouflage (impeding immune priming and infiltration), coercion (suppressing immune function), and cytoprotection (resisting inflammatory death). Crucially, the text evaluates numerous therapeutic strategies aimed at converting these refractory "cold" tumors into…