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Episode 185: Breast Implants Don't Get Rejected - But Capsules Act Like They Do
Capsular contracture after breast implants may look like rejection at the gene level — but it's not rejection. Dr. Robert Whitfield breaks down the fascinating 2025 Larson study from Denmark that analyzed the transcriptome of capsular contracture. This study found ~1,500 differentially expressed genes and an immune signature that MIMICS allograft rejection, with B cells, plasma cells, CD4 T cells and macrophages involved. Learn what RNA sequencing actually shows, what it doesn't prove, and what it means for you. 📚 Study Discussed: Larson et al. (2025) - "Transcriptome of Capsular Contracture…
The skinny
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