336-Eukaryote Assembly Timeline from Dated Gene Duplications
The paper investigates the timing and sequence of events during eukaryogenesis, the origin of eukaryotic cells. The authors use a relaxed molecular clock methodology to date gene duplication events related to key eukaryotic features, particularly those of archaeal and bacterial descent. Their findings suggest that the archaeal host cell was already complex, possessing an elaborated cytoskeleton, endomembrane, and a nucleus/protonucleus, before mitochondrial endosymbiosis occurred. This timeline rejects "mitochondrion-early" models and supports a "complexified-archaeon, late-mitochondrion"…
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