Journal Club: Architecting an Aggressive Cancer
Mechanical forces and architecture may not sound very "bio", but they are key tools of epidermal stem cells. These stem cells essentially engineer their environment by producing both the cells above them (the skin cells) and the extracellular matrix mesh (the basement membrane) that they sit on. In this episode we explore whether, when these stem cells acquire oncogenic mutations (the ones that cause cancer), do they now architect in a different way, and does this influence the development of cancer?
Host Lauren Richardson and Professor Elaine Fuchs of Rockefeller University discuss her lab's…
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