379-Spotiphy: Single-Cell Spatial Across Entire Sections
This research introduces Spotiphy, a new computational method designed to analyze spatially resolved transcriptomics data with high precision. By integrating single-cell and spatial datasets, the authors examine the complex tissue microenvironment in conditions like Alzheimer’s disease and breast cancer. The study successfully identifies specific cell populations, such as disease-associated microglia, and maps their physical proximity to amyloid plaques. Additionally, the researchers utilize these tools to uncover how cell-cell communication and mobility change across different spatial layers…
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