Latest / The Smart Cookies podcast / Staying Healthy In The Age Of The Obesity Epidemic. With Dr. Stephan Guyenet
Transcript
- 0:00And it's a struggle that most people are not
- 0:03going to win. So if you're having to fight, literally
- 0:06fight yourself every day, if you're having to
- 0:10fight these systems, these really survival systems,
- 0:13right, in our brains, these are systems that
- 0:15were forged in the distant past to keep our ancestors
- 0:19alive and reproducing. You're fighting systems
- 0:25that are not really designed to be overridden.
- 0:29They're designed to be in charge and to not let
- 0:32you just, you know, make stupid decisions with
- 0:35your conscious, rational brain, like not eating
- 0:39enough as perceived by these systems. And so
- 0:42if you're fighting those systems every day, you're
- 0:45probably going to lose in the long run. Dr. Stephan
- 0:50Guyenet is a neuroscientist, obesity researcher,
- 0:52and author of the outstanding book, The Hungry
- 0:55Brain, Outsmarting the Instincts. that make us
- 0:58overeat. Dr. Guyenet, welcome to the show. Thanks
- 1:02for having me on, Zaza. As part of my detailed
- 1:05and extremely rigorous research for this interview,
- 1:08I decided to clinically observe myself when I
- 1:10go to the nearest 7 -Eleven, which fortunately
- 1:13or unfortunately sits just outside my house.
- 1:17And it was to my great shame that even though
- 1:20I said to myself that I'm going there just to
- 1:22get some barley tea, I immediately found myself
- 1:25over by the desserts fridge. where I kind of
- 1:28already knew that a particular type of chocolate
- 1:31roll cake will be waiting for me. And it was.
- 1:35And carrying on with the grand experiment, I
- 1:38couldn't help but notice that my arm kind of
- 1:40automatically grabbed the cake and paid for it.
- 1:44And before I could really intervene, I was already
- 1:46staring at the empty, greasy wrapper. And what
- 1:51followed was what always follows, and that's
- 1:53an encounter with an old friend called Guilt.
- 1:56Since you're an expert in exactly this type of
- 2:00behavior, do you mind telling me what happened
- 2:02there? And most of all, why this keeps happening,
- 2:05even though every single time I say to myself,
- 2:07this was, in fact, the last time? Yeah, absolutely.
- 2:11So I think this relates closely to the thesis
- 2:13of my book, which is that there are different
- 2:17brain regions that have different agendas that
- 2:20are all kind of guiding our behavior. Essentially,
- 2:25what you experienced there was a conflict between
- 2:28brain regions that wanted you to obtain certain
- 2:32nutrients, certain calorie -dense nutrients like
- 2:35fat and sugar, especially the combination of
- 2:39those, versus brain regions that are more rational
- 2:43and thoughtful and have goals for you like staying
- 2:48lean, remaining in good health, eating a healthy
- 2:50diet. See, if you didn't have the latter brain
- 2:55regions, then you wouldn't feel any guilt. You
- 2:58would just be eating the food, right? So there's
- 3:01a conflict there, an inner conflict that plays
- 3:06out between these ancient non -conscious or minimally
- 3:10conscious brain regions that determine our eating
- 3:13drive and the conscious rational brain regions
- 3:16that have our higher level rational goals in
- 3:20mind for ourselves. two systems, it's really
- 3:24more than two systems, but for now, we can think
- 3:26about it as two systems are often in conflict.
- 3:31And that leads to a lot of struggle in our lives,
- 3:35it leads to a lot of not meeting the healthy
- 3:40goals that we have for ourselves, such as you
- 3:43experienced. And so in that particular case,
- 3:46what you experienced was a behavior that has
- 3:53been strongly reinforced so there is a lot of
- 3:58motivational drive behind that behavior you've
- 4:01engaged in that behavior previously received
- 4:04a reward for that behavior dopamine was released
- 4:07in your brain and now it's this kind of stamped
- 4:10in automatic complex of motivation and behavior
- 4:14that gets triggered when you're in the environment
- 4:18that allows that behavior. So you've had this,
- 4:21you know, chocolate roll before, every time you
- 4:24have it, your brain, you know, your body senses
- 4:28the nutrients that are in that, that carbohydrate,
- 4:31the sugar, the fat, the flavor, and it knows
- 4:36that on a basic kind of survival level, for our
- 4:41ancestors, when our brains were being shaped,
- 4:43that that's a really important food for survival.
- 4:45That's lots of calories. That's going to help
- 4:47you survive and reproduce in the environment
- 4:50where our brains were being shaped. And so your
- 4:53brain creates a very strong motivation. You get
- 4:55dopamine release. And then that creates a sensitivity
- 5:00to those cues that are associated with it. So
- 5:04next time you walk into the store and you're
- 5:06in the environment where your brain knows you
- 5:08can get that food and you see the food, that
- 5:11triggers the whole motivation and behavior to
- 5:14obtain that and consume it. And so it's this
- 5:17reinforcement loop would be the psychological
- 5:21way to to describe it. That really is, to a large
- 5:27extent, pretty automatic. I mean, I don't mean
- 5:30to say that we can't interrupt it. Like if somebody
- 5:34had put a gun to your head and said, don't eat,
- 5:36you know, don't eat this, you would be able to
- 5:38not eat it. Right. So it's not like it's not
- 5:42like we absolutely can't interrupt it, but it
- 5:45is. I would say effortful and often unreliable
- 5:50to try to disrupt those behaviors when we're
- 5:53in an enabling environment. From what you're
- 5:56saying, does it follow that our ancestors tried
- 5:59to eat one big heavy meal because they didn't
- 6:03know when the next meal is going to be coming
- 6:06from? My best understanding is that if we go
- 6:11back to hunter -gatherers, Our ancestors ate
- 6:15as much as possible whenever they could. And
- 6:18so it wasn't necessarily just one big meal per
- 6:20day. It was whenever they had access to food,
- 6:23they ate as much of it as they possibly could.
- 6:25And that's the impression that I got from speaking
- 6:29with anthropologists. For example, Kim Hill,
- 6:33who studied the Ache hunter -gatherers in South
- 6:37America, he told me that they would absolutely
- 6:40gorge on... things like oranges honey fatty meat
- 6:45and same for the hadza they in um in africa tanzania
- 6:49they that's another hunter -gatherer group that's
- 6:53been well studied by herman poncer and others
- 6:55and herman told me that they don't have any concept
- 7:00of restraint around eating food like the idea
- 7:03of gluttony that we have in western countries
- 7:06that's a modern concept that's not something
- 7:10that our ancestors had Or at least I shouldn't
- 7:13say that's not something that our ancestors had
- 7:15because that's a generalization. But I'll just
- 7:17say based on the anthropologists that I have
- 7:20spoken with, that's not a concept that I have
- 7:23encountered in hunter -gatherer populations.
- 7:27So their concept is not eating too much is bad.
- 7:30Their concept is eating as much as possible is
- 7:33good. And whenever you have the opportunity,
- 7:36because for them, obtaining food is difficult,
- 7:40effortful. and dangerous right and so it's not
- 7:44like they're going to the grocery store and spending
- 7:4810 of their disposable income on food like an
- 7:51american would in in this incredibly abundant
- 7:54environment they have to go out and chase animals
- 7:59and climb trees and dig up tubers and do all
- 8:03kinds of other effortful dangerous uh difficult
- 8:07things to get their food and so and those things
- 8:09cost energy too And so you're always kind of
- 8:12fighting to get enough energy, to get enough
- 8:15nutrients to survive and reproduce. And so it
- 8:19makes sense that if you have an opportunity to
- 8:21eat a ton of calories, if it's right in front
- 8:23of you, right, you're going to eat as much as
- 8:25possible. That means you're not going to have
- 8:28to go out as much the next day and work hard
- 8:31and expose yourself to danger to get additional
- 8:34food. So that's kind of how our brains are wired.
- 8:38And I think that partially explains why we have
- 8:40a tendency to overeat. Our brains are wired to
- 8:43go for the food when it's available because that's
- 8:46what sustained our ancestors. The problem is
- 8:49it's just too easy to acquire. That's a problem,
- 8:52not the only problem, but it's very easy to acquire
- 8:55in the modern food environment. There's almost
- 8:57no effort barrier. Like even let's say, you know,
- 9:01the. You gave the example, what is it, a chocolate
- 9:05roll cake? Roll cake, yeah. Let's not mention
- 9:08it anymore because I'm having difficulties with
- 9:10speaking. Yeah, that's what it was. But it could
- 9:14be, I have a sweet tooth. Okay, so let's say
- 9:17instead of it was at the 7 -Eleven, you had to
- 9:20walk five miles and climb a tree to get that
- 9:23exact same food. I bet you wouldn't eat it as
- 9:26often, right? You would think about it pretty
- 9:30hard if you had to do all that work. to get it.
- 9:33And you probably wouldn't do it as often. And
- 9:35so I think it's not just about the types of foods
- 9:38we're eating. It's about the food environment.
- 9:41What's the effort barrier that's there to eating.
- 9:44And in a hunter gatherer situation where we evolved,
- 9:47there were large effort barriers to eating. And
- 9:51so we had to have that strong motivational drive
- 9:53to get those calories to push us over those effort
- 9:57barriers. Today, we still have those drives,
- 10:00but the effort barrier is almost gone. So when
- 10:04it comes to this type of compulsive eating or
- 10:07whatever, are we dealing with the variant of
- 10:10the old adage that we have paleolithic emotions,
- 10:12medieval institutions and godlike technology
- 10:14in a way only that we can substitute godlike
- 10:17technology with, like you said, an extreme abundance
- 10:19of very accessible calories? Yeah, I think that's
- 10:24right. Probably the piece of that I'd most dispute
- 10:27is the medieval institutions. I think most of
- 10:30our institutions are a lot better than medieval,
- 10:32but... Debatable, but... Yeah, that's outside
- 10:37of my area of expertise. So I'll put that one
- 10:40aside. Yeah, absolutely. So, I mean, our brains
- 10:44were shaped by food environments that are radically
- 10:49different than the current environment. And a
- 10:51lot of what our brains are doing is... underneath
- 10:55our conscious awareness. It's these hardwired,
- 10:59evolutionarily shaped brain systems and brain
- 11:04functions that are very out of step with the
- 11:07modern food environment. So you think about where
- 11:10does hunger come from? We don't decide to generate
- 11:14hunger, right? There's not a conscious process
- 11:16where we're like, oh, it's noon. This is when
- 11:20I normally eat lunch. I'm going to turn on hunger
- 11:23so I can go eat. exactly the right amount of
- 11:25food, right? We don't decide when hunger is going
- 11:28to come. We don't decide how much hunger is going
- 11:31to come. We don't decide how much food it's going
- 11:34to take to satisfy that hunger. We don't decide
- 11:37what kind of cravings we have. These are all
- 11:40things that arise from non -conscious brain processes,
- 11:43right? And what's shaping these brain processes?
- 11:46These are hardwired brain systems. They're hardwired,
- 11:50but That doesn't mean they can't be influenced
- 11:52by the environment. I just want to say that.
- 11:54These are brain systems that evolved to operate
- 11:57and are calibrated for a specific environment.
- 11:59And that environment is no longer the one we're
- 12:03living in. And so, yeah, I think we do. I don't
- 12:07want to say that we, saying that we have paleolithic
- 12:10minds, I think is a little too narrow. I think
- 12:14our minds have been shaped by evolution. past
- 12:21the paleolithic period we're not exactly hunter
- 12:24-gatherers anymore most of us certainly are there
- 12:27has not been enough time in the industrial food
- 12:30system for our evolution to catch up to that
- 12:34so and then so that's that's that piece of it
- 12:37and then you said the godlike technology thing
- 12:39and yeah i think you know i'll you know godlike
- 12:43is a kind of uh you know a strong way to put
- 12:49it but I think we have become extremely good
- 12:53at satisfying our own food preferences. So we
- 12:59have these kind of innate food preferences that
- 13:02we're all born with, like an infant, a newborn
- 13:06likes the taste of sugar. You can put sugar on
- 13:09a newborn's tongue and they will have facial
- 13:13expressions of pleasure. And that's hardwired
- 13:17into rats. You can do the same thing to a rat
- 13:19pup and it will have facial expressions of pleasure.
- 13:22These are very deeply wired, evolutionarily conserved
- 13:26preferences. We like sugar. We like fat. We like
- 13:29starch. We like, to a certain extent, protein.
- 13:33We like those calorie -delivering macronutrients,
- 13:38calorie -delivering molecules that enhanced our
- 13:44survival and reproduction in ancient times and
- 13:48we like to get them as easily as possible we
- 13:52don't like to work hard for them and we like
- 13:55to get them in delightful combinations so not
- 13:59just you know a pile of plain sugar we like to
- 14:03have the flavors in it you know we like to have
- 14:06the fruity flavors and the chocolate flavors
- 14:08we like to have the fat and the sugar mixed together
- 14:12like in chocolate or chocolate roll cakes, sorry,
- 14:16and other foods like that, pizza, whatever it
- 14:22is. I mean, you think about almost any food that
- 14:25people really struggle to control their eating
- 14:27around. Typically, it's a combination of fat
- 14:30and carbohydrate because those two things, they're
- 14:32synergistic together in our brains. It's like,
- 14:35oh, it's not just one good thing. It's two good
- 14:37things together in the same food. And then you
- 14:40put the salt on it as well, which is also a motivating
- 14:42factor. You put the, you know, fruity or chocolatey
- 14:47flavors or whatever. It comes together in a way
- 14:50that is extremely enticing for these hardwired
- 14:55motivational systems and can become hard to control
- 14:58in many people. And so, you know, coming back
- 15:01to the comment you made about godlike technology,
- 15:04you look at like a fruit, a piece of fresh fruit.
- 15:09that our ancestors would have had access to that
- 15:11is not a very calorie -dense food. It's mostly
- 15:15water, right? If you look at an apple or wild
- 15:19berries, it's mostly water. It's got a lot of
- 15:22fiber in it. It may not have exactly the flavor
- 15:25you prefer. It might have a little bit of bitterness
- 15:27or off flavors of some kind. But what did we
- 15:30learn how to do? Gradually, we learned how to
- 15:33say, hey, what is the thing in there we like?
- 15:36What's the thing in there that we really like?
- 15:38It's the sugar, right? How do we purify that
- 15:41even more? And how do we continue doing that
- 15:44until we have the absolute most purified version
- 15:47of that possible pure granulated sugar? And then
- 15:51how do we take that and we mix it together with
- 15:54the absolute most purified version of other dopamine
- 15:58stimulating nutrients like fat? and salt and
- 16:02all those things so we're basically taking the
- 16:05active ingredient the active ingredient that
- 16:08triggers our motivation we're purifying it to
- 16:12the max where our ancestors could never have
- 16:14done that you know monosodium glutamate that's
- 16:17another great example and we're combining it
- 16:20in these combinations that just um are excessively
- 16:25motivating and so That's how we end up with these
- 16:29very strong reinforcement loops that end up with
- 16:32the types of behaviors that you observed in yourself.
- 16:35But even people who don't experience exactly
- 16:40what you described, those things still tend to
- 16:43push us to eat too much. So maybe you'll have
- 16:46a little bit more on your plate. You'll consume
- 16:49a little bit more than you would have if it were
- 16:51totally unrefined, simple foods like our ancestors
- 16:55used to eat. I noticed that I never or rarely
- 17:00overeat on vegetables. Processed foods, such
- 17:04as this unfortunate roll cake that's made in
- 17:07some soulless factory, is another matter entirely.
- 17:13Is that why processed foods are so bad for us?
- 17:16I think there are multiple reasons why processed
- 17:18foods are bad for us, but I would say probably
- 17:21the number one reason is that we tend to overconsume
- 17:26them. And by the way, the term processed foods
- 17:30has been defined in many ways and people kind
- 17:32of debate what the best way to define it and
- 17:36what's really bad about it. And so I'm not going
- 17:38to get into all that, but I'll just say that
- 17:40I don't think processing per se is necessarily
- 17:44harmful. I think it depends on how foods are
- 17:47processed. So when the processing is removing
- 17:50fiber, removing nutrients. making things more
- 17:53calorie dense, making things more delicious.
- 17:57I think that's when it tends to not be as healthy.
- 18:04It tends to promote overeating. But, you know,
- 18:09there are other forms of processing that are
- 18:11probably harmless. Like if you're getting 100
- 18:13% whole wheat bread, that is a processed food.
- 18:19You know, and maybe there are even preservatives
- 18:21in it. Maybe there are other ingredients in it
- 18:24that you might not recognize. Probably most of
- 18:27those are harmless, honestly. And you're probably
- 18:30better off eating that than grandma's homemade
- 18:34brownies from scratch because of the fact that
- 18:39those brownies are more likely to lead to overeating
- 18:43than the whole grain bread is. I'm dying to ask
- 18:48you how I can trick the brain into performing
- 18:50a big switcheroo with healthier foods, but let's
- 18:53park this for now and I promise we'll come back
- 18:55to it later on. We have to for my own sake. But
- 18:57since you're an obesity researcher, I wanted
- 18:59to ask you, why do we usually become obese? What
- 19:04happens there? Yeah, so there are different ways
- 19:09that we can look at it. One way is... The simple
- 19:14way, the kind of physics way, which is that there
- 19:18has to be a consistent excess of calorie intake
- 19:21over calorie expenditure over a period of time.
- 19:25So in other words, we have to eat more than our
- 19:27body is burning for a period of time. When you
- 19:30do that, your body accumulates fat. But there
- 19:34is a larger question of why we do that. And I
- 19:40think that question can also be addressed from
- 19:43different angles. And one of them is that we
- 19:49actually have regulatory systems for body fatness
- 19:52and appetite in our bodies. It's not just something
- 19:55that happens by accident passively. So if we
- 20:00have these regulatory systems, why is it that
- 20:03our body fat changes over time? Shouldn't a regulatory
- 20:07system? keep body fat within a certain range
- 20:10over time. And we don't really have a complete
- 20:16answer to this question, but the body fat regulatory
- 20:19systems seem to change over time. So people who
- 20:24are initially regulating around a lean body,
- 20:30so in other words, if they overeat a little too
- 20:34much one day, they might undereat. The next day,
- 20:37not doing it on purpose, it's just their regulatory
- 20:40system is working. When they get to middle age,
- 20:44maybe now they're heavier, they've gained some
- 20:47weight, and their regulatory system is regulating
- 20:50at that new weight. So if they, let's say this
- 20:54person has developed obesity in middle age, if
- 20:58they then try to lose weight to get back down
- 21:01to where they were when they were, let's say,
- 21:0420 years old. their regulatory system is actually
- 21:08going to fight them. So it's going to be difficult
- 21:12to lose that weight. And if they do get back
- 21:14down to the weight where they were when they
- 21:16were 20, it will be a lot harder to maintain
- 21:19that loss than it was to maintain that weight
- 21:22when they were 20 and their regulatory system
- 21:25was in a different place. So you see this over
- 21:28and over again in weight loss studies. People
- 21:32lose weight. But then over the course of the
- 21:34next year, they regain it. That's the typical
- 21:37trajectory for someone who tries to lose weight
- 21:40over using diet and lifestyle. It doesn't mean
- 21:44diet and lifestyle is hopeless, but the effects
- 21:47are definitely limited by pushback from this
- 21:50regulatory system. Sorry to interrupt you, but
- 21:54why is the baseline moving upwards as we age?
- 21:57Is that necessarily always the case? No, it's
- 22:00not necessarily always the case. and I'll give
- 22:03you two reasons for that. One is that there are
- 22:05individuals who it doesn't happen for. Probably
- 22:10a lot of that is genetics. Some of it I'm sure
- 22:13is diet and lifestyle, but there are also entire
- 22:17cultures that that doesn't happen in. And there
- 22:21aren't a lot of them anymore because the whole
- 22:23world is industrializing. But if you look at
- 22:25cultures, hunter gatherers or subsistence farmers
- 22:30who are living in a, more ancestral human way,
- 22:34many of those cultures don't gain fat at all
- 22:38as they age. And you'll see as they transition
- 22:41to an industrial diet, they will start to gain
- 22:44fat as they age. But when they're eating a traditional
- 22:49diet, body fat is essentially stable for their
- 22:53entire lives. Is that because the diet has changed?
- 22:58Because I presume that they still, you said they're
- 23:00subsistence farmers, they're still working, they're
- 23:02still physically active, right? Oh, so you're
- 23:05asking how much of it is diet versus other things?
- 23:08Exactly. Yeah. Yes. Versus activity or physical
- 23:12activity, I mean. I feel fairly confident that
- 23:16it's mostly diet. I think that physical activity
- 23:19could be playing some role, but physical activity
- 23:22is a less powerful lever over body fatness than
- 23:26diet is. Diet is really the most powerful lever.
- 23:30So I'm originally a rodent researcher. So we
- 23:33were doing a lot of studies on obesity and rodents.
- 23:36They're actually a pretty good model for human
- 23:38obesity. They respond similarly to humans in
- 23:41many ways to diet and to drugs and things like
- 23:45that. And one of the nice things about rodents
- 23:48is you can very tightly control conditions of
- 23:52diet, of lifestyle, et cetera. And what I can
- 23:56tell you... is that human junk food is extremely
- 24:02fattening in rodents. The most fattening thing
- 24:06you can do to a normal rodent that doesn't involve
- 24:09surgery or drugs is feed a diet of calorie -dense,
- 24:14highly palatable human foods. You give them a
- 24:17variety of foods. You give them free, unlimited
- 24:21access. You can even put their normal healthy
- 24:24chow in the same cage. They'll completely ignore
- 24:26it. They'll eat all of these chocolate rolls
- 24:31and everything else. Big Macs. Yeah. Candy, sausages,
- 24:36just whatever calorie dense, highly palatable
- 24:39food you can think of. Cookies. They will absolutely
- 24:43stuff their faces on it and they will rapidly
- 24:46develop obesity. And there is nothing else you
- 24:50can do. to a rodent a normal rodent that doesn't
- 24:56involve surgery or drugs or thing you know unusual
- 25:00things like that that will make them that fat
- 25:03there's no you can even make pellets like pelleted
- 25:07foods that are high in fat that are high in sugar
- 25:09there is no macronutrient or combination of macronutrients
- 25:14in a pellet that replicates that can fully replicate
- 25:19the fattening effects of human junk food. It's
- 25:24the entire package. It's the variety. It's the
- 25:28combination of fat and carbohydrate. It's the
- 25:31calorie density. It's the flavors. It's everything
- 25:34all together is extremely fattening. It's not
- 25:38just rodents either. I mean, you see like bears
- 25:41that are eating through human trash, animals
- 25:44that are fed by tourists, like they develop obesity.
- 25:47Basically, any species, and this has been experimentally
- 25:51tested also in a variety of species, pretty much
- 25:53any species that is omnivorous and has the ability
- 25:56to gain body fat, some animals don't, will develop
- 26:01obesity on the current human diet. It's extremely
- 26:07fattening across many different species. use
- 26:14other levers like let's say now we're looking
- 26:17at physical activity that can affect body fatness
- 26:20too but the effect is much more limited so a
- 26:24couple different ways to look at this if you
- 26:26have mice and rats on a regular chow diet like
- 26:29a healthy rodent diet and you don't let them
- 26:32exercise they will gradually gain a little bit
- 26:35of fat over the course of their lives as they
- 26:37age they will get a bit fatter not to the point
- 26:40of obesity but you know they'll get a little
- 26:44pudgy um now if you have them exercise they will
- 26:48not they will stay lean for their entire lives
- 26:51now if you put them on an unhealthy diet an obesity
- 26:55um promoting diet and you give them exercise
- 26:58it will mitigate the fat gain so they won't gain
- 27:02as much fat as they would have if they didn't
- 27:06have the exercise but they'll still be much fatter
- 27:09than an animal that is not receiving that fattening
- 27:13diet so and you see the same thing in humans
- 27:16like if you look at randomized controlled trials
- 27:19so that i don't know how much your your audience
- 27:22knows about study designs but this is a type
- 27:25of rigorous study where you're putting people
- 27:28you're randomizing people to different conditions
- 27:30you're you have a control group it's considered
- 27:33the gold standard of trying to understand how
- 27:36one thing affects the other in biomedical science
- 27:39so You can put people on different diets. You
- 27:42can put people on different exercise regimes.
- 27:45If you look across the literature, diet just
- 27:48affects body fatness a lot more than exercise.
- 27:54Exercise does affect body fatness. I'm not discounting
- 27:57it completely, but it's just not as powerful
- 28:00of a lever. And when the brain is trying to regulate
- 28:03your body fatness up or down, appetite is the
- 28:06main lever it's pulling. If I understand you
- 28:08correctly, exercise is more relevant when it
- 28:11comes to maintaining your weight than losing
- 28:15it, right? I think that's right. I mean, I think
- 28:18it's helpful for weight loss as well, but I do
- 28:21think that it is more helpful for maintenance
- 28:23than it is for loss. I also will say I think
- 28:27exercise is very important for health and for
- 28:32physical functioning as we age. So I don't mean
- 28:35to say that exercise is not important. I think
- 28:38it is important. I do a lot of it. But it's just
- 28:42not the most powerful lever for body fatness
- 28:45specifically. What role does genetics play in
- 28:49us being more or less susceptible to weight gain?
- 28:52Because we all have that one friend who eats
- 28:54like a whale but goes to the toilet like eight
- 28:56times a day and is just perpetually skinny. And
- 28:59it's not fair. Yeah, it's powerful. Genetics
- 29:03is powerful. And I think... Like you said, we
- 29:06can really make common sense observations among
- 29:09people that we see and come to that conclusion.
- 29:11Right. So we all know people who just don't care
- 29:16about diet at all and stay lean. And, you know,
- 29:19maybe they're fit as well. They can run faster
- 29:24than you, even though they don't take care of
- 29:25themselves. I think we all know people like that.
- 29:29And then there are other people who seem like
- 29:32they're. obsessed with diet. They eat healthy
- 29:35food and they are heavier. Maybe they even have
- 29:43obesity. So yeah, genetics is huge. And if you
- 29:49look at the studies that have actually measured
- 29:51that, depending on the type of study, the range
- 29:55of variation in body fatness between people,
- 30:00that is explained by genetics is somewhere in
- 30:03the 40 to 80 % range. So yeah. So in other words,
- 30:1040 to 80 % of why one person is lean and another
- 30:15person has obesity is thought to be due to genetics.
- 30:20And there's debate about which number is more
- 30:23accurate. But that's, I think it's somewhere
- 30:26in that range. Yeah. So it's actually... a very
- 30:30powerful factor and you know it runs in families
- 30:32it's not just about it's not just about the diet
- 30:36that people eat in families when kids get adopted
- 30:38into different families their body fatness tends
- 30:41to be more about who their parents were than
- 30:44how their adoptive parent their adoptive family
- 30:48lives and if you look at what is underlying those
- 30:54genetics it's mostly about how the brain is constructed
- 30:58and how the brain operates the genetics the specific
- 31:02genes that vary that cause one person to be fatter
- 31:08one person leaner mostly about how our brain
- 31:11is put together well despite the different genetic
- 31:15makeups that we have there is an obesity epidemic
- 31:17especially in the west what do you think is going
- 31:22on there I want to start by just expressing a
- 31:25little bit of intellectual humility that we don't
- 31:29know for sure. We can't run experiments where
- 31:33we randomize different countries to different
- 31:35treatments and rerun history a hundred times.
- 31:40So the best we can do is look at the evidence
- 31:42we have experimentally from human trials, from
- 31:46animals, and then observational evidence from
- 31:48what has changed over time in parallel with...
- 31:52body fatness um that's interesting because before
- 31:56you said that um you were telling me about these
- 31:59communities of subsistence farmers and as soon
- 32:02as their diets changed to our modern diets it
- 32:06was easier for them to become obese so i was
- 32:09i was thinking the answer is going to be very
- 32:10simple well the answer is going to be diet okay
- 32:15ultimately but i'm just i'm just uh i'm just
- 32:18expressing uncertainty because right we don't
- 32:21really know like i think there's you know i don't
- 32:24think this is likely but i don't think it's impossible
- 32:26that we learn that oh actually it wasn't really
- 32:30the food it was some contaminant or it wasn't
- 32:34really the food it was some microbe or an infection
- 32:37something like that so there are other there
- 32:40are other hypotheses i don't think they're as
- 32:43well supported but i'm just trying to tell you
- 32:46that this You know, what I'm going to say is
- 32:49pieced together is my best guess from the available
- 32:51evidence. It's not a rock solid home run. But,
- 32:55you know, what I was telling you before that
- 32:57food is the biggest lever over body fatness.
- 33:01Well, our diets have changed radically over the
- 33:04course of the obesity epidemic. And I think that
- 33:08to me is by far the most likely suspect. If you
- 33:12look at. yeah it's not just our diet what i the
- 33:16term i typically use is our food environment
- 33:18that's broader than just the foods that go into
- 33:21our bodies it's about how those foods show up
- 33:25in our environment how food cues show up in our
- 33:29environment because you know if you go back just
- 33:32in the united states 100 years our diet if you
- 33:36just look at the foods we were eating it's probably
- 33:38at least as bad as it was today maybe worse i
- 33:41mean People were eating a ton of white flour
- 33:45100 years ago in the United States, ton of white
- 33:48flour. We weren't eating that much less sugar
- 33:51than we are today. We're already eating a diet
- 33:54pretty high in sugar. We're eating less meat.
- 33:56We're eating less vegetables. We're eating less
- 33:59fruit. And so the diet was very kind of refined
- 34:04and monolithic. But. We were eating it in a different
- 34:11context where everything was cooked at home.
- 34:15I shouldn't say everything, but the vast majority
- 34:18of food was cooked at home. There was not a huge
- 34:21abundance and diversity of different kinds of
- 34:24foods in the grocery store or in hardware store
- 34:27checkout lines or everywhere at 7 -Eleven all
- 34:31around us. And, you know, because foods had to
- 34:35be prepared, we were eating them at mealtimes.
- 34:37It's not like we had snacks laying on the counter
- 34:40all the time. People were not often drinking
- 34:42sugar sweetened beverages, caloric beverages
- 34:45between meals. So even though the diet wasn't
- 34:49necessarily healthy in terms of its composition,
- 34:54the way our food environment operated. we were
- 34:57not over consuming it as much. That's just to
- 35:00illustrate that I don't think it's just about
- 35:02the specific foods that we're eating. But I do
- 35:05think it is also about the foods that we're eating.
- 35:08So it's partly about the environment that we're
- 35:10in, that lowers the effort barrier to eating
- 35:12that puts foods and food cues around us constantly.
- 35:16And it's partly about the fact that the foods
- 35:18that we're eating are on average, more seductive,
- 35:21more calorie dense. And probably easier to consume
- 35:26like not as much chewing not as much you know
- 35:31than they were originally so basically i think
- 35:35all of those things coming together over time
- 35:37is is the main reason for the obesity epidemic
- 35:41it doesn't make sense i used to spend a lot of
- 35:44time in france and you know there's a bakery
- 35:47on every corner and it's just white white flour
- 35:51and butter croissants and like baguettes are
- 35:54flying off the shelf the shelves like it's nobody's
- 35:57business and yet french people seem really fit
- 36:00on average um so it it kind of confirms what
- 36:04you were saying but i want to ask another question
- 36:07i live in japan actually and contrary to popular
- 36:10belief if you don't live in like rural okinawa
- 36:13or something don't actually eat all that healthy
- 36:16like fried foods are everywhere so are sweets
- 36:18so is fast food so is 7 -eleven like i told you
- 36:20so is alcohol However, the people, again, are
- 36:24very lean. It's really hard, even in Tokyo, to
- 36:27spot an obese person. And even when you do, it's
- 36:29usually a Western tourist. I'm not going to lie.
- 36:32The one thing that is true, however, is that
- 36:34the portions here are noticeably small everywhere.
- 36:38When people eat at home, when they eat in a restaurant,
- 36:40even in like a 7 -Eleven packaging of sweets,
- 36:42it's going to be much smaller than in the West.
- 36:46And then people tend to walk a lot, but we talked
- 36:48about exercise already. Why do you think the
- 36:50difference might be so dramatic then? Is it the
- 36:53smaller portions or is it genetics? Yeah, so
- 36:58I want to address the genetics question first.
- 37:01I think it's mostly not genetics. And the reason
- 37:04I say that is because there is a study that was
- 37:08done of migrants from Japan to the United States
- 37:12and what happens to their body weight and health.
- 37:15And what they found is that migrants gained a
- 37:18lot of weight when they migrated to the United
- 37:20States, specifically Hawaii. So would they become
- 37:25exactly as obese over time, over generations?
- 37:28I can't answer that question, but certainly the
- 37:32genetics does not protect them against gaining
- 37:37a substantial amount of fat in the United States
- 37:39when they immigrate. So I don't think genetics
- 37:43is a great explanation for it. I think the food
- 37:47environment makes a lot more sense. I think there
- 37:52are, well, I'll start with the easy part and
- 37:55then we'll get into the hard part. The easy part
- 37:58is if you look at the diet in Japan, it is less
- 38:04calorie dense, lower in fat, higher in carbohydrate
- 38:08than the diet in... Hawaii. So I think when they
- 38:13moved to the United States, the diet basically
- 38:15got richer. I'm sure they were eating more calories
- 38:18as well. So that's the easier piece. The harder
- 38:24piece is kind of why that happened. And I think
- 38:30that gets down to a question that is really hard
- 38:33to study, which is culture, food culture. And
- 38:37I think that Japan has a culture around eating
- 38:43and meal times and portions that is different
- 38:46than the American culture around those things.
- 38:50It's really hard to study that. It's really hard
- 38:52to quantify the causal impact of that on eating
- 38:57behavior and body fatness. But I think when you
- 39:01have data like the one that I explained about
- 39:03the migrant study, it's hard to think of. You
- 39:08know, it's it's hard to account for those observations
- 39:12without placing at least some weight on food
- 39:15culture as an explanation, I think. And I think
- 39:18the same is true in France. I have strong connections
- 39:20with France. My dad is French. And I see how
- 39:24they eat. It's in most cases pretty different
- 39:29than how we eat here in the United States, partially
- 39:32in the types of foods that they're eating. But,
- 39:34you know, the food, most of it is. cooked at
- 39:38home. Uh, they're, they eat less processed foods.
- 39:42They don't eat a lot between meals. So there's
- 39:46not like snacks laying around that people can
- 39:48just grab whenever they want. It's really common
- 39:50in the United States actually for people to not
- 39:54really even have meals like in, like in families,
- 39:58not sitting down together for meals. There's
- 40:01just food in the fridge. There's food in the,
- 40:03in the pantry and people just grab it whenever.
- 40:07They're hungry and there's a variety of different
- 40:08things. So, you know, kids can have whatever
- 40:11they prefer. And that's that's like that would
- 40:15be inconceivable to most French families. I mean,
- 40:20I'm sure things are changing over time, but like
- 40:23the traditional French way of eating, that would
- 40:25be like the absolute antithesis of it. You're
- 40:28there's not food laying around. Everyone comes
- 40:30together for meals. Most of the meals are made
- 40:33are prepared from. Fresh ingredients. Yeah. Again,
- 40:38it's hard to quantify. It's hard to make a really
- 40:40hard argument for this. But I think just cross
- 40:46-cultural comparison, to me, it's very likely
- 40:50that food culture plays an important role in
- 40:55the obesity epidemic. No, that totally makes
- 40:57sense. Although probably even in Europe, it's
- 41:00likely going to change with food that's delivered
- 41:03through an app. While you're working at home.
- 41:06And I think it is changing. Yeah, I think it
- 41:08has changed over time. And I think that's reflected
- 41:11in body fatness. And, you know, even in Europe,
- 41:15their body fatness is going up, depending on
- 41:18the country. UK is not that far behind the United
- 41:21States. You know, so even within Europe, it varies
- 41:25quite a bit. Yep. Last one on this matter, and
- 41:30then I'll stop, I promise. What about booze?
- 41:33If you take that away from me, I'll have next
- 41:35to no consolations left. If I want to lose some
- 41:37weight, like, do I have to give up alcohol at
- 41:42all costs? I mean, you don't have, no, you don't
- 41:45have to give up alcohol at all costs. But I think
- 41:47alcohol is certainly a factor that makes weight
- 41:51control more difficult, particularly depending
- 41:54on the type of alcohol. So alcohol is inherently
- 41:58high in calories. So I think one standard U .S.
- 42:04drink, which would be like a beer or a glass
- 42:09of wine or an ounce and a half of spirits. I
- 42:13know I'm using American measures here. Apologies.
- 42:18That the alcohol in that has, if I'm recalling
- 42:21correctly, about 90 calories. But in a beer,
- 42:25you don't just have the alcohol you have. additional
- 42:29carbohydrate. And in a mixed drink where it's
- 42:33sweet, for example, you would also have additional
- 42:35carbohydrates. So I would say the first move
- 42:37would be to drink lower calorie types of alcohol.
- 42:41So wine or spirits, dry wine or spirits have
- 42:46lower calorie per drink. But again, alcohol is
- 42:51inherently pretty high in calories. And then,
- 42:54I mean, really the big picture is If you're trying
- 42:58to control your body fatness, it's not just about
- 43:03individual foods. It's about the big picture.
- 43:06How many calories are you consuming in total?
- 43:09Because you could have a very healthy, high satiety,
- 43:17lower calorie dense diet, and then you could
- 43:20have a drink or two every day and still be losing
- 43:24weight. So it really depends on the total dietary
- 43:28context, not just individual things that you're
- 43:32doing. So alcohol is going to tend to push weight
- 43:35up because of its caloric value. But that doesn't
- 43:38mean, you know, it's just one lever in the overall
- 43:41picture. Are there any studies on psychological
- 43:45states in the foods that we eat? Because again,
- 43:48with myself, I'm going to notice that if I need
- 43:50some soothing, I'm again going to go for the
- 43:53worst thing possible. Is there any correlation
- 43:55between, I don't know, trauma and overeating?
- 43:59Yes, there are correlations between trauma and
- 44:04body fatness and eating disorders. So people
- 44:08who have early life trauma tend to have a higher
- 44:15risk of developing excess body fatness and developing
- 44:19eating disorders like binge eating and things
- 44:23like that. Yeah, so I think there is a connection
- 44:26there. And I also, you know, I want to be clear
- 44:30that I don't think that explains all of it. So,
- 44:33you know, I don't think you can see a person
- 44:36with obesity and say, oh, they're, they have
- 44:39excess fat, because they, you know, had some
- 44:42traumatic thing when they were a kid, or they're
- 44:45stressed or whatever. I think it's a factor that
- 44:47can contribute. Yeah. And I think what you said
- 44:51is basically correct that When we're stressed,
- 44:55food can help soothe us. And there's been studies
- 44:59on this where the brain systems that are activated
- 45:02in stress, you can directly measure that the
- 45:05activity in those regions go down when we get
- 45:08comfort foods, which are typically these highly
- 45:13rewarding calorie dense foods. Like when you
- 45:17want to feel soothed, you're not usually going
- 45:20to be eating celery and lentils, right? Yeah,
- 45:23why is a cauliflower not soothing me? What's
- 45:26up with that? Yeah, yeah. Why does it have to
- 45:29be pancakes with Nutella, you know? Yeah, absolutely.
- 45:33I think it's because pancakes with Nutella is
- 45:38a lot more pleasurable to you. And so, you know,
- 45:42the pleasure of that dampens those stress circuits
- 45:46more. So I guess we finally come full circle
- 45:50and you can tell me how to trick my prehistoric
- 45:53brain so it's going to treat a zucchini the same
- 45:56way it treats a slice of pepperoni pizza. Well,
- 46:00I don't want to overpromise here. I don't think
- 46:02I'm going to get anyone to enjoy a zucchini.
- 46:07Anyway, but I think there are ways to work with
- 46:12these systems better. I think, you know, we started
- 46:15off this conversation talking about this conflict
- 46:17that often occurs between these hardwired, non
- 46:21-conscious brain systems that determine our motivation,
- 46:23hunger, etc. Conflict of those systems versus
- 46:28the conscious, rational brain regions that are
- 46:32trying to manifest our higher level goals like
- 46:36health and longevity and physical appearance,
- 46:40etc. Looking good in a bathing suit. And there's
- 46:44that conflict. And so that, you know, sets up
- 46:49a very difficult struggle for many people. And
- 46:54it's a struggle that most people are not going
- 46:57to win. So if you're having to fight, literally
- 47:00fight yourself every day, if you're having to
- 47:04fight these systems, these really survival systems,
- 47:07right, in our brains, these are systems that
- 47:09were forged. in the distant past to keep our
- 47:13ancestors alive and reproducing, you're fighting
- 47:18systems that are not really designed to be overridden.
- 47:22They're designed to be in charge and to not let
- 47:26you just, you know, make stupid decisions with
- 47:29your conscious, rational brain, like not eating
- 47:33enough as perceived by these systems. If you're
- 47:37fighting those systems every day, you're probably
- 47:39going to lose in the long run. So my approach
- 47:43is how do we get those systems to align? How
- 47:47do we get those two systems to align so you're
- 47:50not fighting yourself anymore? And to do that,
- 47:53you have to know how to speak the language of
- 47:56these systems. What do they want? What do they
- 47:59respond to? There are a couple of different angles
- 48:02we can look at this from, but one of them is
- 48:05we can look at. the satiety system, which is
- 48:08the system that determines how full we feel at
- 48:11a individual meal. And so that system is trying
- 48:15to make sure that you get enough food, but not
- 48:17too much in a particular meal. And it turns out
- 48:22that that system, how full it makes you feel
- 48:24and when it tells you to stop eating at a meal,
- 48:27depends a lot on what you're eating. So if you're
- 48:31eating foods that are very calorie dense, in
- 48:34other words, have a lot of calories per gram
- 48:37of food. So those would be foods that don't have
- 48:40much water, have a lot of fat, that don't have
- 48:43a lot of fiber. Those kinds of foods are not
- 48:46going to fill you up as much per calorie. So
- 48:50each calorie that you eat, essentially you're
- 48:53going to have to eat more calories to achieve
- 48:55that feeling of fullness that tells you to stop
- 48:57the meal. And that would be the, you know, kind
- 49:01of foods that people intuitively recognize as
- 49:04fattening, like pizza and cakes and cookies and
- 49:10things like that, fried foods. So calorie density
- 49:16is one thing. Low -protein foods are not as filling
- 49:22per calorie. Low -fiber foods are not as filling
- 49:25per calorie. Foods that are highly palatable,
- 49:28so foods that are... you know, the ones that
- 49:31we really, really love to eat, those are not
- 49:33as filling per calorie. It's like your brain
- 49:37shuts off satiety a little bit to get more of
- 49:40this desired food. And so conversely, if we eat
- 49:45foods that are lower in calorie density, higher
- 49:48in protein, higher in fiber, these are things
- 49:51that are more like what our distant ancestors
- 49:52would have eaten, kind of fresh meats, fresh
- 49:55fruits and vegetables, whole grains, eggs. those
- 50:00types of foods without a lot of added fat, those
- 50:04things tend to make us feel full with fewer calories.
- 50:08So that way, you know, that way you're kind of
- 50:13aligning the satiety system with your higher
- 50:16level goals for yourself instead of the alternative
- 50:19would be, you know, this I'm kind of caricaturing
- 50:22this as an extreme example, but you. sit down
- 50:27the way to generate maximum conflict would be
- 50:29you sit down to a meal of let's say pizza and
- 50:33ice cream and a and a soda and you say okay i'm
- 50:40gonna sit down to this meal but i'm only gonna
- 50:42eat uh i'm gonna do portion control i'm only
- 50:46gonna eat half the amount of calories that i
- 50:49would normally eat of this because i'm on a weight
- 50:51loss diet that is going to be really difficult
- 50:54Because your brain is going to be saying, I really
- 50:56want to eat way more of this. And the other part
- 51:01of your brain is going to be saying, no, I'm
- 51:03on a diet. I don't want to eat this. That's the
- 51:06conflict situation. So if you're giving your
- 51:09satiety system foods that allow it to feel full
- 51:12with fewer calories, then you're aligning those
- 51:14two systems. So that's one way. Another way is
- 51:20the system that... is by working with the system
- 51:23that generates cravings and so this is the one
- 51:27that brought you to that chocolate roll cake
- 51:29right this is the reward system because you probably
- 51:32weren't well i don't know i'm making assumptions
- 51:35here but you probably weren't going for it because
- 51:37you were feeling hungry right it wasn't like
- 51:39your assumptions are completely correct yeah
- 51:42okay i'm never hungry when i had it yeah okay
- 51:44yeah so it's not like oh i really need some food
- 51:47i'm so hungry i need to get this it's more like
- 51:49this is a food that i really love and i feel
- 51:54the motivation for so i'm going to go get it
- 51:56even if i'm not hungry and so that's a different
- 51:59brain system than the one that regulates hunger
- 52:02and satiety and um that's the food reward system
- 52:06and so for that one it's very driven by environmental
- 52:12cues so if you're in that 7 -eleven where you
- 52:17would normally buy that food that's a cue for
- 52:19your brain that triggers the craving if you never
- 52:22went into that 7 -eleven you're not gonna you're
- 52:26probably not going to trigger that craving or
- 52:28not as much and it will probably if you do have
- 52:31a little bit of it probably be easy to inhibit
- 52:33that behavior so really what um the best way
- 52:38to address that system is to control your food
- 52:42environment so you're controlling the cues that
- 52:45you're giving your brain You're not giving it
- 52:47the cues that stimulate that craving, which would
- 52:50be anything associated with that food. So you're
- 52:54not leaving it on the counter so you can see
- 52:56it. You're not leaving it in places where it
- 52:59would be very easy to access and your brain knows
- 53:02that, like the counter is a good example. You're
- 53:06not walking by places where you smell the fresh
- 53:10baked bread, you know, the bakery or whatever.
- 53:16limiting your exposure to food advertising that's
- 53:19showing you pictures of you know the foods that
- 53:22might stimulate your your craving you're not
- 53:24going to the locations where you would typically
- 53:27eat um a food that you don't want to eat it's
- 53:31the same it's really the same playbook as quitting
- 53:34smoking it's exactly the same playbook um living
- 53:38in japan you know it's a very densely populated
- 53:41country especially if you're in tokyo so i might
- 53:45as well like lock myself in a buddhist monastery
- 53:47it is certainly more difficult in some uh food
- 53:53environments than others i acknowledge that it
- 53:56can be difficult if there are families with kids
- 53:58um which is the case for me i mean you you seem
- 54:03to be in really good shape if you don't mind
- 54:05me saying and what works best for you is it the
- 54:10triggers removing the triggers or is it the satiety
- 54:13I do all of it. Or is it both? I do all of it.
- 54:15And I probably also have relatively favorable
- 54:20genetics. I probably would have, if I didn't
- 54:23care at all about nutrition or, you know, exercise
- 54:26or whatever, I probably would have a little potbelly,
- 54:29but I don't think I would have obesity. No one
- 54:33in my family has real obesity. So I think there
- 54:37is some favorable genetics. Just want to acknowledge
- 54:39that. But also, yeah, no, I control food cues.
- 54:44I don't have most of the time I don't have foods
- 54:48that I that aren't consistent with my goals in
- 54:51my house. There are some exceptions to that.
- 54:53Having a kid in the house, I am not really able
- 54:56to be as strict as I want to be with myself.
- 55:00But I also tend to eat foods that have a high
- 55:05satiety per calorie value. So like my breakfast,
- 55:08for example, is. oatmeal cooked in water with
- 55:11fat -free Greek yogurt and blueberries. And so
- 55:18that's a lot of protein, a lot of fiber, low
- 55:22calorie density, and it keeps me full for a long
- 55:24time. I limit my snacks in between meals. And
- 55:31then there's also exercise as well. I run and
- 55:34I do weightlifting and lots of yard work and
- 55:37stuff like that. Yeah, I try. I don't make it
- 55:40easy for myself to eat food. Like mostly if I
- 55:42want to eat, I have to cook something. There
- 55:47are a few exceptions, but nothing that's very
- 55:52tempting, like unsalted roasted nuts, for example.
- 55:57I could get some of those if I wanted to in the
- 56:00kitchen, but I'm not going to do that unless
- 56:02I'm really hungry because it's just not that
- 56:04tempting. Or a piece of fresh fruit. so um it
- 56:10helps if they're covered in chocolate yeah that's
- 56:14right so i do all of it yeah basically and i'm
- 56:17not extreme about it i i eat a pretty moderate
- 56:20diet um but right so you're not like that longevity
- 56:24guy brian johnson who eats like one carrot stick
- 56:27and 324 supplements a day yeah no um okay that
- 56:33Yeah. Anyway, I won't comment on that, but that's
- 56:36not what I do. And, and that works for me, but
- 56:41I also, you know, if, if I had, if I actually
- 56:44had obesity or I was more susceptible to it,
- 56:47I might be stricter than I am. But yeah, I do,
- 56:51I do a light to moderate version of all those
- 56:53things that we discussed. And I think that. In
- 56:59a country like the United States, the lifetime
- 57:01prevalence of obesity is over 50%. That's probably
- 57:05going to change with the GLP -1 drugs. But if
- 57:08you don't do anything in the United States, chances
- 57:12are you are going to gain fat and you're going
- 57:15to become unhealthy if you're just going with
- 57:18the flow. And I don't want to do that. I don't
- 57:21want that to happen to me. I don't want that
- 57:23to happen to my family. And so I'm doing what
- 57:26I need to do to... control that risk at least
- 57:30to a reasonable degree for the end i wanted to
- 57:34ask you a more broad question about navigating
- 57:37this impossible informational landscape that
- 57:41we're inhabiting right now where we're flooded
- 57:43with information but at the same time it's hard
- 57:45to know what's really backed up by science and
- 57:47what's some random guy eating raw liver on tiktok
- 57:50and telling you it's healthy as a rule of thumb
- 57:53what kind of food or diet for lack of a better
- 57:57word would you then recommend to ordinary folks?
- 58:01You know, it's also a problem with these food
- 58:03groups that keep changing. When I was growing
- 58:05up, they said carbohydrates, that fats are the
- 58:08worst. And then they were saying sugar is the
- 58:11worst. And now I even read that protein is not,
- 58:14if you eat too much of it, it can be inflammatory.
- 58:17So it's not good. So, you know, it's always,
- 58:21it's changing so fast that you can just give
- 58:24up on all of it. I think there's some truth to
- 58:28what you're saying. But I also think that what's
- 58:33been changing a lot is kind of what is most prevalent
- 58:37in our media environment, not necessarily what
- 58:41the research is saying. So I do think the opinions
- 58:45in the research community have shifted somewhat
- 58:47over time around fat, for example. But the perception
- 58:52that like... sugar used to be okay and now it's
- 58:56the devil i don't think the research community
- 58:59has really shifted that much on sugar i think
- 59:02um maybe maybe to some degree it has but i think
- 59:07it's always been viewed like you can go back
- 59:10to the 1980 dietary guidelines for americans
- 59:13in the u .s and one of the points it focused
- 59:17on was eating less sugar so they cared about
- 59:21it back then they care about it now but It's
- 59:23not the boogeyman. It's still not the boogeyman
- 59:26that it's made out to be in the media right now.
- 59:29I think the importance of it has been exaggerated.
- 59:32So that's just to say that I think we live in
- 59:35an information environment with podcasts and
- 59:37social media and things where things can change
- 59:40really rapidly and it can be hard to get good
- 59:42information. And a lot of the information that
- 59:45is there is low quality. And that's the information
- 59:47that people are mostly receiving. But that doesn't
- 59:51necessarily reflect the best assessments by the
- 59:56most knowledgeable people. And I think those
- 59:59have changed to some extent, but a lot less over
- 1:00:03time. Yeah, so I would say to someone who just
- 1:00:06wants to generally maintain health and leanness,
- 1:00:09what I would recommend is eating a minimally
- 1:00:13processed omnivorous diet that is lower in calorie
- 1:00:17density and higher in... Protein, the protein
- 1:00:22you may or may not want to do, but that's more
- 1:00:24for people who want to control body fatness,
- 1:00:29who have that as a concern, may not be necessary
- 1:00:32depending on your goals. And then if you're someone
- 1:00:35who really is struggling with fat gain or you
- 1:00:40currently have obesity and you want to lose weight,
- 1:00:43you can use additional levers like you can increase
- 1:00:48the protein more. And I'm talking about lean
- 1:00:51protein, not protein that has a lot of fat associated
- 1:00:54with it. And you can consider other approaches
- 1:00:59like macronutrient restriction, like restricting
- 1:01:02the carbohydrate, restricting the fat in the
- 1:01:05diet. And you can also consider things like portion
- 1:01:09control, which doesn't have a great track record,
- 1:01:13but it is a tool that some people use successfully.
- 1:01:16Very last thing. What about diets? I reckon then
- 1:01:21you wouldn't recommend any of these like diet
- 1:01:23fats such as like keto or paleo or Atkins, low
- 1:01:28fat, whatever, gluten free. Is it beneficial?
- 1:01:31Is it not? I think some of these diets can be
- 1:01:34useful tools. I mean, I think they're tools in
- 1:01:36the tool belt. And I think they work better for
- 1:01:40some people than for others. But, you know, a
- 1:01:42low carbohydrate diet, it's been around for a
- 1:01:45long time and some people it works well for.
- 1:01:49You know, I think the thing that the only caveat
- 1:01:53I would have about it is that it tends to get
- 1:01:57oversold. So people act like this is the solution
- 1:02:01to your weight problem. Just go on a low carb
- 1:02:03diet. And if and if it's not working for you,
- 1:02:05just make it even more low carb and then go zero
- 1:02:08carb. And if it's still not working, you're probably
- 1:02:10not doing it right. You know, and the truth is,
- 1:02:14like, these diets are not as effective as people
- 1:02:16want them to be. But that doesn't mean they're
- 1:02:18not effective. they can be effective and particularly
- 1:02:21for certain individuals, they can be very effective.
- 1:02:24So I think it's a tool in the tool belt, you
- 1:02:27know, and some are better than others. Like the
- 1:02:29low carb diets are pretty well established. The
- 1:02:33only thing I would say is if you're going to
- 1:02:35do a low carb diet, don't have it be just like
- 1:02:38a, you know, processed meat diet, try to do more
- 1:02:42lean meats and vegetables include some fruits,
- 1:02:46things like that. It's fine to cut back on the,
- 1:02:49The grains, those are not really critical elements
- 1:02:52to diet, in my opinion. And then there are other
- 1:02:57options like low -fat plant -based diets. That's
- 1:03:02another pretty well -worn path that people have
- 1:03:05done successfully. And there are other pitfalls
- 1:03:09you want to watch for, like make sure if you're
- 1:03:12not eating animal foods, take a vitamin B12 supplement.
- 1:03:15That's really the big one. So I think there are
- 1:03:18plenty of diets out there that actually do have
- 1:03:20a fair amount of effectiveness. But really, you
- 1:03:24just want to make sure that whatever diet you're
- 1:03:27doing, you're sticking to having dietary diversity.
- 1:03:32So you're getting all your nutrients. You want
- 1:03:34to continue eating fiber. Don't go off the deep
- 1:03:38end with these diets in a way where you're not
- 1:03:40eating something that an expert would recognize
- 1:03:43as a reasonably healthy diet. um as some people
- 1:03:48do and very last question just because i thought
- 1:03:51of it right now and your answer can be brief
- 1:03:53we talked about goals we talked about how to
- 1:03:56lose weight how to maintain a healthy weight
- 1:03:58but what is a healthy body is this body type
- 1:04:05that we're being sold i don't know in commercials
- 1:04:08from hollywood you know guys that are really
- 1:04:10jacked and for women it's different of course
- 1:04:12is that actually a healthy body or not you know
- 1:04:16all these muscles um that you probably don't
- 1:04:19really need or should you aspire to be more lean
- 1:04:22to actually be healthy or even have a little
- 1:04:25bit of a beer belly i don't know you tell me
- 1:04:27yeah yeah so i think certainly the the hollywood
- 1:04:32body type is an unrealistic ideal for most people
- 1:04:36and unnecessary um particularly when it comes
- 1:04:41to the muscularity of the men Like if you go
- 1:04:44back and you look at movies that were produced
- 1:04:46even 30, 40 years ago, superhero movies and things
- 1:04:52like that, people were not nearly as muscular.
- 1:04:55The idea that superheroes or whatever protagonist
- 1:04:59needs to be like extremely jacked, that's a really
- 1:05:02recent Hollywood thing. So I think that kind
- 1:05:06of body is unrealistic. I don't think it's necessarily
- 1:05:09unhealthy. I think it could be if you start getting
- 1:05:13into the really low body fat levels. I don't
- 1:05:17think it's healthy to aspire to permanently have
- 1:05:23body fat in the low single digits like a bodybuilder
- 1:05:27would have during competition. And I mean, it
- 1:05:31would be very difficult to maintain that regardless.
- 1:05:33But there is such a thing as going too far. But
- 1:05:37in general, I think having a lean body is a good
- 1:05:40thing. I think the one of the, I would argue
- 1:05:45that probably the number one driver of health
- 1:05:48problems in the United States is excess body
- 1:05:50fatness. And so, and in many other countries
- 1:05:54as well, but I'm most confident about the United
- 1:05:58States. And it probably used to be smoking, but
- 1:06:03not as many people smoke anymore and people are
- 1:06:06a lot fatter than they used to be. So I think
- 1:06:08today it's probably. excess body fatness um so
- 1:06:13i think having to a point low body fatness is
- 1:06:18good not taking it to an extreme but to to a
- 1:06:22healthy low body fat percentage and i think having
- 1:06:25higher muscle mass is also good so i would call
- 1:06:30that a you know favorable body composition taking
- 1:06:33both the fat and the muscle mass into account
- 1:06:35um but i don't think that it's realistic to aspire
- 1:06:41to look like a hollywood actor for either men
- 1:06:45or women right like that's just i mean that that's
- 1:06:49just a psychological trap like you're never going
- 1:06:51to be satisfied you probably don't have the genetics
- 1:06:54to look like that the average person doesn't
- 1:06:56have the genetics to look like that you don't
- 1:06:59have the trainers and the money to look like
- 1:07:01that you don't have the special effects and the
- 1:07:04lighting to look like that like it's uh You're
- 1:07:07just going to cause yourself psychological pain,
- 1:07:09and that's not necessary for excellent health.
- 1:07:14Dr. Guyanet, thank you so much. This was amazing.
- 1:07:17Where can people get your book? Find bookstores
- 1:07:20everywhere? Yeah, yeah. My book is available.
- 1:07:24I don't know about internationally as much, but
- 1:07:27it's available on Amazon here in the U .S. and
- 1:07:30in English -speaking countries. In the US, it's
- 1:07:34available in many libraries. I know it's available
- 1:07:38in my local library. And internationally, I'm
- 1:07:43sure you could order it through Amazon US and
- 1:07:46maybe through your own country's Amazon. I'm
- 1:07:50not sure about that. We'll include the link in
- 1:07:53the description. Thanks again. Thank you. Thank
- 1:07:55you so much for listening. There's a gazillion
- 1:07:57podcasts out there, but you chose this one. So
- 1:07:59I really appreciate your attention. If you're
- 1:08:02feeling extra generous, you can always hop on
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- 1:09:04Thanks again, guys. You're the best.