1428-Decoding Neddylation in Malignancies
This review article explores neddylation, a vital protein modification process that significantly influences cancer development and progression. The authors detail how this enzymatic cascade regulates protein stability, localization, and function, thereby sustaining various cancer hallmarks such as immune evasion, metabolic rewiring, and therapeutic resistance. While typically viewed as oncogenic, the text highlights that neddylation can have dual effects depending on the specific tumor environment and cellular stress factors like hypoxia. By examining the molecular mechanisms and…
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