208-PHLOWER: Inferring Differentiation Trajectories
The article introduces PHLOWER, a novel computational method for inferring complex, multi-branching cell differentiation trajectories from single-cell multimodal data, such as RNA sequencing and ATAC sequencing. By leveraging the harmonic component of the Hodge decomposition on simplicial complexes, PHLOWER translates cell differentiation into flow embeddings that facilitate the reconstruction of intricate differentiation trees. The authors demonstrate PHLOWER's superior performance through extensive benchmarking against competing methods using both simulated and real single-cell…
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